Notch receptors influence cellular behavior by participating in a seemingly simple signaling
pathway, but outcomes produced by Notch signaling are remarkably varied depending on …

The diagnostic category of Burkitt’s lymphoma encompasses a closely related group of
aggressive B-cell tumors that includes sporadic, endemic, and human immunodeficiency virus–…

Notch signaling plays a key role in the normal development of many tissues and cell types,
through diverse effects on differentiation, survival, and/or proliferation that are highly …

Dependable, current, and complete, Robbins and Cotran Pathologic Basis of Disease, 9th
Edition is the perennially best-selling text that you’ll use long after your medical student days …

… And finally, Vinay Kumar and Abul Abbas welcome ]on Aster, who cut his teeth on the eighth
edition of Pathologic Basis of Disease, as a co-author and editor. Our partnership thrives …

Very rare cases of human T cell acute lymphoblastic leukemia (T-ALL) harbor chromosomal
translocations that involve NOTCH1, a gene encoding a transmembrane receptor that …

Diffuse large B-cell lymphoma (DLBCL), the most common lymphoid malignancy in adults,
is curable in less than 50% of patients. Prognostic models based on pre-treatment …

Effective anti-tumour immunity in humans has been associated with the presence of T cells
directed at cancer neoantigens 1 , a class of HLA-bound peptides that arise from tumour-…

Background Understanding the interactions between tumor and the host immune system is
critical to finding prognostic biomarkers, reducing drug resistance, and developing new …

… Hardy,3 also transmembrane proteins, such as Jagged1 (Lindsell Jon C. Aster,4 and
Warren S. Pear1,5 et al., 1995), Jagged2 (Shawber et al., 1996; Luo et al., 1Department of …