Background The 69th World Health Assembly approved the Global Health Sector Strategy
to eliminate hepatitis C virus (HCV) infection by 2030, which can become a reality with the …

Here we describe the insights gained from sequencing the whole genomes of 2,636 Icelanders
to a median depth of 20×. We found 20 million SNPs and 1.5 million insertions-deletions (…

Background Since the release of the first global hepatitis elimination targets in 2016, and until
the COVID-19 pandemic started in early 2020, many countries and territories were making …

Background The risk of recurrence of gastrointestinal stromal tumour (GIST) after surgery
needs to be estimated when considering adjuvant systemic therapy. We assessed prognostic …

Clonal hematopoiesis (CH) arises when a substantial proportion of mature blood cells is
derived from a single dominant hematopoietic stem cell lineage. Somatic mutations in …

The BRCA2 gene on chromosome 13 has been shown to be associated with familial male
and female breast cancer. Here we describe a study on BRCA2 in 21 Icelandic families, …

In order to search for sequence variants conferring risk of thyroid cancer we conducted a
genome-wide association study in 192 and 37,196 Icelandic cases and controls, respectively, …

Gastrointestinal stromal tumor (GIST) is a newly defined clinical and pathologic entity. This
study examines the whole population‐based incidence of GIST as well as pathologic risk …

Ovarian cancer causes more deaths than any other gynecologic malignancy in developed
countries. Sixteen million sequence variants, identified through whole-genome sequencing of …

The objective of the study was to assess the risk of second primary cancers (SPCs) following
a primary head and neck cancer (oral cavity, pharynx and larynx) and the risk of head and …