Calorie restriction, without malnutrition, has been shown to increase lifespan and is associated
with a shift away from glycolysis toward beta-oxidation. The objective of this study was to …

Energy restriction (ER), without malnutrition, increases maximum life span and retards the
development of a broad array of pathophysiological changes in laboratory rodents. The …

An epidemic of obesity has affected large portions of the world, increasing the risk of developing
many different age-associated diseases, including cancer, cardiovascular disease, and …

Reductions in cellular oxygen consumption (V̇o 2 ) and reactive oxygen species (ROS)
production have been proposed as mechanisms underlying the anti-aging effects of calorie …

Long-term caloric restriction (CR) has been shown to extend maximum life span in laboratory
rodents. We investigated the activities of gluconeogenic and transaminase enzymes in the …

Calorie restriction (CR) without malnutrition increases life span and delays the onset of a
variety of diseases in a wide range of animal species. However, the mechanisms responsible …

Caloric restriction (CR) retards diseases and aging in laboratory rodents and is now being
tested in nonhuman primates. One way to apply these findings to human health is to identify …

The causes of the decline in skeletal muscle mass and function with age, known as sarcopenia,
are poorly understood. Nutrition (calorie restriction) interventions impact many cellular …

This volume and issue of The Journal of Nutrition marks the 75th anniversary of the
publication by McCay, Crowell, and Maynard entitled “The Effect of Retarded Growth upon the …

Maintaining a healthy body weight requires an exquisite balance between energy intake and
energy expenditure. To understand the genetic and environmental factors that contribute to …