The nematode Caenorhabditis elegans is a unique whole animal model system for identifying
small molecules with in vivo anti-infective properties. C. elegans can be infected with a …

The opportunistic pathogen Pseudomonas aeruginosa causes serious human infections,
but effective treatments and the mechanisms mediating pathogenesis remain elusive. …

Influenza A viruses (IAVs) inhibit host gene expression by a process known as host shutoff.
Host shutoff limits host innate immune responses and may also redirect the translation …

Notch signaling is critical for cell fate decisions during development. Caenorhabditis elegans
and vertebrate Notch ligands are more diverse than classical Drosophila Notch ligands, …

Sensory physiology has been shown to influence female mate choice, yet little is known
about the mechanisms within the brain that regulate this critical behaviour. Here we examine …

Combinations of three or more drugs are used to treat many diseases, including tuberculosis.
Thus, it is important to understand how synergistic or antagonistic drug interactions affect …

Background The conserved DOS-motif proteins OSM-7 and OSM-11 function as coligands
with canonical DSL (Delta, Serrate, and LAG-2) ligands to activate C. elegans Notch …

Candida albicans, the most common human pathogenic fungus, can establish a persistent
lethal infection in the intestine of the microscopic nematode Caenorhabditis elegans. The C. …

Staphylococcus aureus, the leading cause of hospital-acquired infections in the United
States, is also pathogenic to the model nematode Caenorhabditis elegans. The C. elegans-S. …

The nematode Caenorhabditis elegans offers currently untapped potential for carrying out
high-throughput, live-animal screens of low molecular weight compound libraries to identify …