Keratoconus (KC) is a progressive corneal ecstasia characterized by thinning and weakening
of the cornea that leads to a cone-like appearance, scarring, and decreased vision. …

The ‘MHC-I (major histocompatibility complex class I)-opathy’ concept describes a family of
inflammatory conditions with overlapping clinical manifestations and a strong genetic link to …

HLA class I alleles constitute established risk factors for non-infectious uveitis and preemptive
genotyping of HLA class I alleles is standard practice in the diagnostic work-up. The HLA-…

Birdshot chorioretinopathy (BSCR) is a rare form of autoimmune uveitis that can lead to
severe visual impairment. Intriguingly, >95% of cases carry the HLA-A29 allele, which defines …

… Jonas JW Kuiper graduated in biomedical sciences in 2009 in the field of immunity &
infection, and is a PhD trainee at the Department of Ophthalmology, University Medical Centre …

Importance The diagnostic workup of patients suspected of having vitreoretinal lymphoma (VRL)
is primarily based on vitreous fluid analysis, including the recently emerging myeloid …

Birdshot Uveitis (Birdshot) is a rare eye condition that affects HLA-A29-positive individuals
and could be considered a prototypic member of the recently proposed ‘MHC-I (major …

Genomic studies in age-related macular degeneration (AMD) have identified genetic
variants that account for the majority of AMD risk. An important next step is to understand the …

Objective Uveitis is a visually debilitating disorder that affects up to 30% of children with the
most common forms of juvenile idiopathic arthritis ( JIA ). The disease mechanisms …

Objective Childhood uveitis is a vision‐threatening inflammatory eye disease commonly
attributed to juvenile idiopathic arthritis (JIA). The pathogenesis is poorly understood, which …