Differentiation and activation of T cells require the activity of numerous histone lysine
methyltransferases (HMT) that control the transcriptional T cell output. One of the most potent …

The fidelity of T cell immunity depends greatly on coupling T cell receptor signaling with
specific T cell effector functions. Here, we describe a chromatin-based mechanism that enables …

Humoral immunity in mammals relies on the function of two developmentally and functionally
distinct B‐cell subsets—B1 and B2 cells. While B2 cells are responsible for the adaptive …

Humoral immunity in mice and man relies on the function of two developmentally and functionally
distinct B cell subsets - B1 and B2 cells. While B2 cells are responsible for most of the …

Dysfunction of the endolysosomal system is often associated with neurodegenerative
disease because postmitotic neurons are particularly reliant on the elimination of intracellular …

Importance Elevated systolic blood (SBP) pressure is a leading global health risk. Quantifying
the levels of SBP is important to guide prevention policies and interventions. Objective To …

Importance Cancer is among the leading causes of death worldwide. Current estimates of
cancer burden in individual countries and regions are necessary to inform local cancer control …

Background Disability and mortality burden of non-communicable diseases (NCDs) have
risen worldwide; however, the NCD burden among adolescents remains poorly described in …

This article presents an acknowledgment by the Human & Experimental Toxicology the
contribution of the reviewers. The reviewers listed in the article are Ahokas Jorma, Alam Mesbah, …

Background: Organ fibrosis due to excessive production of extracellular matrix by resident
fibroblasts is estimated to contribute to >45% of deaths in the Western world, including those …