[HTML][HTML] A topographic atlas defines developmental origins of cell heterogeneity in the human embryonic lung

…, E Braun, C Avenel, J Bergenstråhle, J Theelke… - Nature Cell …, 2023 - nature.com
The lung contains numerous specialized cell types with distinct roles in tissue function and
integrity. To clarify the origins and mechanisms generating cell heterogeneity, we created a …

[PDF][PDF] ATF4-induced warburg metabolism drives over-proliferation in Drosophila

S Sorge, J Theelke, K Yildirim, H Hertenstein… - Cell Reports, 2020 - cell.com
The mitochondrial electron transport chain (ETC) enables essential metabolic reactions;
nonetheless, the cellular responses to defects in mitochondria and the modulation of signaling …

[HTML][HTML] Local tissue interactions govern pLL patterning in medaka

…, K Gross, J Onistschenko, OP Hoang, J Theelke… - Developmental …, 2022 - Elsevier
Vertebrate organs are arranged in a stereotypic, species-specific position along the animal
body plan. Substantial morphological variation exists between related species, especially so …

Postnatal FGFR-signaling establishes gradients of secretory cell identities along the proximal-distal axis of the lung airways

A Sountoulidis, AB Firsova, A Liontos, J Theelke… - bioRxiv, 2023 - biorxiv.org
The spatial organization and developmental control of cell maturation in the branched
airway epithelium are only partially understood. Here, we labelled the major adult secretory …

Developmental origins of cell heterogeneity in the human lung

…, J Bergenstråhle, M Vicari, P Czarnewski, J Theelke… - BioRXiv, 2022 - biorxiv.org
The lung contains numerous specialized cell-types with distinct roles in tissue function and
integrity. To clarify the origins and mechanisms generating cell heterogeneity, we created a …

Topographic atlas of cell states identifies regional gene expression in the adult human lung

…, Z Andrusivova, A Sountoulidis, J Theelke… - 2024 - diva-portal.org
Single cell mRNA sequencing of the whole organ has become a popular technique to reveal
rare types and subtypes of previously characterized cells as well as to distinguish and …

An ATF4-mediated transcriptional adaptation of electron transport chain disturbance primes progenitor cells for proliferation in vivo

S Sorge, J Theelke, C Altbürger, I Lohmann - bioRxiv, 2018 - biorxiv.org
The mitochondrial electron transport chain (ETC) enables many important metabolic
reactions, like ATP generation and redox balance. While the vital importance of mitochondrial …

Molecular Determinants of Synaptic Specificity at the Single Cell Level

J Velten - 2021 - archiv.ub.uni-heidelberg.de
The correct wiring of neuronal circuits represents one of the most complex processes throughout
development. Mistakes in their formation underly genetic neuropathies including autism …

FGF-dependent mechanosensory organ patterning in zebrafish

A Nechiporuk, DW Raible - Science, 2008 - science.org
During development, organ primordia reorganize to form repeated functional units. In
zebrafish (Danio rerio), mechanosensory organs called neuromasts are deposited at regular …

[HTML][HTML] Evolutionary genetics of canine respiratory coronavirus and recent introduction into Swedish dogs

…, S Larsson, R van Damme, AK Theelke… - Infection, Genetics and …, 2020 - Elsevier
Canine respiratory coronavirus (CRCoV) has been identified as a causative agent of canine
infectious respiratory disease, an upper respiratory infection affecting dogs. The …