In an often rapidly changing environment, cells must adapt by monitoring and reacting quickly
to extracellular stimuli detected by membrane‐bound receptors and proteins. Reversible …

The spindle assembly checkpoint (SAC) is the major surveillance system that ensures that
sister chromatids do not separate until all chromosomes are correctly bioriented during mitosis…

Members of the eukaryotic Cdc25 phosphatase family are key targets of the Chk1 and Chk2
checkpoint kinases, which inactivate Cdc25 to halt cell cycle progression when DNA is …

The signaling pathways that sense adverse stimuli and communicate with the nucleus to
initiate appropriate changes in gene expression are central to the cellular stress response. …

The spindle checkpoint is the prime cell-cycle control mechanism that ensures sister chromatids
are bioriented before anaphase takes place. Aurora B kinase, the catalytic subunit of the …

Human papillomavirus type 16 (HPV16) is the most common cause of cervical carcinoma.
Cervical cancer develops from low-grade lesions that support the productive stages of the …

The accurate segregation of chromosomes at mitosis depends on a correctly assembled
bipolar spindle that exerts balanced forces on each sister chromatid 1 , 2 . The integrity of …

The Schizosaccharomyces pombe stress-activated Sty1p/Spc1p mitogen-activated protein (MAP)
kinase regulates gene expression through the Atf1p and Pap1p transcription factors, …

The COP9/signalosome complex is conserved from plant to mammalian cells. In Arabidopsis,
it regulates the nuclear abundance of COP1, a transcriptional repressor of …

We identified a truncated allele of dam1 as a multicopy suppressor of the sensitivity of cdc13‐117
(cyclin B) and mal3‐1 (EB‐1) cells to thiabendazole, a microtubule poison. We find that …