Transient receptor potential vanilloid member 1 (TRPV1) is a Ca 2+ -permeable cation
channel that serves as the primary heat and capsaicin sensor in humans. Using cryo-EM, we …

Finding the conditions to stabilize a macromolecular target for imaging remains the most
critical barrier to determining its structure by cryo-electron microscopy (cryo-EM). While …

Tomographic reconstruction of cryopreserved specimens imaged in an electron microscope
followed by extraction and averaging of sub-volumes has been successfully used to derive …

Protein ubiquitination is an essential process that rapidly regulates protein synthesis, function,
and fate in dynamic environments. Within its non-proteolytic functions, we showed that K63…

Subpopulations of ribosomes are responsible for fine tuning the control of protein synthesis
in dynamic environments. K63 ubiquitination of ribosomes has emerged as a new …

The senataxin (SETX, Sen1 in yeasts) RNA-DNA hybrid resolving helicase regulates multiple
nuclear transactions, including DNA replication, transcription, and DNA repair, but the …

Twinkle is the mammalian helicase vital for replication and integrity of mitochondrial DNA.
Over 90 Twinkle helicase disease variants have been linked to progressive external …

The pluripotency factor Lin28 is a highly conserved protein comprising a unique combination
of RNA-binding motifs, an N-terminal cold-shock domain and a C-terminal region …

Lin28 inhibits the biogenesis of let-7 miRNAs through direct interactions with let-7 precursors.
Previous studies have described seemingly inconsistent Lin28 binding sites on pre-let-7 …

Lewy body dementias are pathologically defined by the deposition of α-synuclein fibrils into
inclusions throughout the brain. Cerebrospinal fluid(CSF) in disease harbors circulating α-…