[HTML][HTML] Sorting and packaging of RNA into extracellular vesicles shape intracellular transcript levels
Background Extracellular vesicles (EVs) are released by nearly every cell type and have
attracted much attention for their ability to transfer protein and diverse RNA species from donor …
attracted much attention for their ability to transfer protein and diverse RNA species from donor …
The transcription factor ERG recruits CCR4–NOT to control mRNA decay and mitotic progression
X Rambout, C Detiffe, J Bruyr, E Mariavelle… - Nature Structural & …, 2016 - nature.com
Control of mRNA levels, a fundamental aspect in the regulation of gene expression, is
achieved through a balance between mRNA synthesis and decay. E26-related gene (Erg) …
achieved through a balance between mRNA synthesis and decay. E26-related gene (Erg) …
PP2A regulatory subunit Bα controls endothelial contractility and vessel lumen integrity via regulation of HDAC7
M Martin, I Geudens, J Bruyr, M Potente… - The EMBO …, 2013 - embopress.org
To supply tissues with nutrients and oxygen, the cardiovascular system forms a seamless,
hierarchically branched, network of lumenized tubes. Here, we show that maintenance of …
hierarchically branched, network of lumenized tubes. Here, we show that maintenance of …
ERG transcription factors have a splicing regulatory function involving RBFOX2 that is altered in the EWS-FLI1 oncogenic fusion
…, MM Aynaud, A Chakraborty, J Bruyr… - Nucleic Acids …, 2021 - academic.oup.com
ERG family proteins (ERG, FLI1 and FEV) are a subfamily of ETS transcription factors with
key roles in physiology and development. In Ewing sarcoma, the oncogenic fusion protein …
key roles in physiology and development. In Ewing sarcoma, the oncogenic fusion protein …
[HTML][HTML] Dephosphorylation of HDAC4 by PP2A-Bδ unravels a new role for the HDAC4/MEF2 axis in myoblast fusion
Muscle formation is controlled by a number of key myogenic transcriptional regulators that
govern stage-specific gene expression programs and act as terminal effectors of intracellular …
govern stage-specific gene expression programs and act as terminal effectors of intracellular …
Expanding the HDAC druggable landscape beyond enzymatic activity
…, J Lakhani, K Song, ZC Yeoh, B Hu, AC Varca, J Bruyr… - bioRxiv, 2022 - biorxiv.org
Enzymatic pockets such as those of histone deacetylases (HDACs) are among the most
favored targets for drug development. However, enzymatic inhibitors often exhibit low selectivity …
favored targets for drug development. However, enzymatic inhibitors often exhibit low selectivity …
[HTML][HTML] The cytoskeleton adaptor protein Sorbs1 controls the development of lymphatic and venous vessels in zebrafish
A Veloso, A Bleuart, L Conrard, T Orban, J Bruyr… - BMC biology, 2024 - Springer
Background Lymphangiogenesis, the formation of lymphatic vessels, is tightly linked to the
development of the venous vasculature, both at the cellular and molecular levels. Here, we …
development of the venous vasculature, both at the cellular and molecular levels. Here, we …
Expanding the HDAC druggable landscape beyond enzymatic inhibition
…, J Lakhani, K Song, ZC Yeoh, B Hu, AC Varca, J Bruyr… - bioRxiv, 2022 - biorxiv.org
Enzymatic pockets such as those of histone deacetylases (HDACs) are among the most
favored targets for drug development. However, enzymatic inhibitors often exhibit low selectivity …
favored targets for drug development. However, enzymatic inhibitors often exhibit low selectivity …
FET fusion oncoproteins hijack the LASR complex to rewire alternative splicing in sarcomas
…, L Ongena, L Dubois, B Galvan, J Bruyr… - … Conference in Splicing …, 2023 - orbi.uliege.be
The FET (FUS, EWSR1, TAF15) genes are commonly involved in chromosomal translocations
resulting in their fusion with various transcription factors (TF) genes. These genomic …
resulting in their fusion with various transcription factors (TF) genes. These genomic …
Quantitative and qualitative regulation of gene expression by FET oncogenic fusions
L Ongena, E Lucarelli, L Dubois, J Bruyr… - … Gene Regulation: From …, 2023 - orbi.uliege.be
Gene fusions involving FET (FUS, EWSR1 and TAF15) genes encode for potent oncoproteins
that act as driver transcription factors in multiple sarcomas and leukemias. While these …
that act as driver transcription factors in multiple sarcomas and leukemias. While these …