Global, regional, and national disability-adjusted life years (DALYs) for 306 diseases and injuries and healthy life expectancy (HALE) for 188 countries, 1990–2013 …
…, H Brenner, AD Briggs, PM Brooks, JC Brown… - The Lancet, 2015 - thelancet.com
Background The Global Burden of Disease Study 2013 (GBD 2013) aims to bring together
all available epidemiological data using a coherent measurement framework, standardised …
all available epidemiological data using a coherent measurement framework, standardised …
[HTML][HTML] Forecasting life expectancy, years of life lost, and all-cause and cause-specific mortality for 250 causes of death: reference and alternative scenarios for 2016 …
Background Understanding potential trajectories in health and drivers of health is crucial to
guiding long-term investments and policy implementation. Past work on forecasting has …
guiding long-term investments and policy implementation. Past work on forecasting has …
[HTML][HTML] The furin cleavage site in the SARS-CoV-2 spike protein is required for transmission in ferrets
…, OC Swann, R Kugathasan, R Penn, JC Brown… - Nature …, 2021 - nature.com
SARS-CoV-2 entry requires sequential cleavage of the spike glycoprotein at the S1/S2 and
the S2ʹ cleavage sites to mediate membrane fusion. SARS-CoV-2 has a polybasic insertion (…
the S2ʹ cleavage sites to mediate membrane fusion. SARS-CoV-2 has a polybasic insertion (…
Global, regional, and national age-sex specific all-cause and cause-specific mortality for 240 causes of death, 1990-2013: a systematic analysis for the Global Burden …
…, N Breitborde, H Brenner, ADM Briggs, JC Brown… - The Lancet, 2015 - cris.unibo.it
Background Up-to-date evidence on levels and trends for age-sex-specifi c all-cause and
cause-specifi c mortality is essential for the formation of global, regional, and national health …
cause-specifi c mortality is essential for the formation of global, regional, and national health …
Global, regional, and national incidence and mortality for HIV, tuberculosis, and malaria during 1990–2013: a systematic analysis for the Global Burden of Disease …
Background The Millennium Declaration in 2000 brought special global attention to HIV,
tuberculosis, and malaria through the formulation of Millennium Development Goal (MDG) 6. …
tuberculosis, and malaria through the formulation of Millennium Development Goal (MDG) 6. …
Global and national burden of diseases and injuries among children and adolescents between 1990 and 2013: findings from the global burden of disease 2013 study
Importance The literature focuses on mortality among children younger than 5 years.
Comparable information on nonfatal health outcomes among these children and the fatal and …
Comparable information on nonfatal health outcomes among these children and the fatal and …
[HTML][HTML] Self-amplifying RNA SARS-CoV-2 lipid nanoparticle vaccine candidate induces high neutralizing antibody titers in mice
…, K Hu, AK Blakney, K Samnuan, JC Brown… - Nature …, 2020 - nature.com
The spread of the SARS-CoV-2 into a global pandemic within a few months of onset motivates
the development of a rapidly scalable vaccine. Here, we present a self-amplifying RNA …
the development of a rapidly scalable vaccine. Here, we present a self-amplifying RNA …
[PDF][PDF] The SARS-CoV-2 variant, Omicron, shows rapid replication in human primary nasal epithelial cultures and efficiently uses the endosomal route of entry
TP Peacock, JC Brown, J Zhou, N Thakur… - …, 2022 - pdfs.semanticscholar.org
At the end of 2021 a new SARS-CoV-2 variant, Omicron, emerged and quickly spread across
the world. It has been demonstrated that Omicron’s high number of Spike mutations lead to …
the world. It has been demonstrated that Omicron’s high number of Spike mutations lead to …
[HTML][HTML] The global burden of tuberculosis: results from the Global Burden of Disease Study 2015
Background An understanding of the trends in tuberculosis incidence, prevalence, and mortality
is crucial to tracking of the success of tuberculosis control programmes and identification …
is crucial to tracking of the success of tuberculosis control programmes and identification …
The altered entry pathway and antigenic distance of the SARS-CoV-2 Omicron variant map to separate domains of spike protein
TP Peacock, JC Brown, J Zhou, N Thakur, K Sukhova… - biorxiv, 2022 - biorxiv.org
At the end of 2021 a new SARS-CoV-2 variant, Omicron, emerged and quickly spread across
the world. It has been demonstrated that Omicron’s high number of Spike mutations lead to …
the world. It has been demonstrated that Omicron’s high number of Spike mutations lead to …