[HTML][HTML] The effects of lowering LDL cholesterol with simvastatin plus ezetimibe in patients with chronic kidney disease (Study of Heart and Renal Protection): a …
C Baigent, MJ Landray, C Reith, J Emberson… - The Lancet, 2011 - thelancet.com
Background Lowering LDL cholesterol with statin regimens reduces the risk of myocardial
infarction, ischaemic stroke, and the need for coronary revascularisation in people without …
infarction, ischaemic stroke, and the need for coronary revascularisation in people without …
RoB 2: a revised tool for assessing risk of bias in randomised trials
…, HY Cheng, MS Corbett, SM Eldridge, JR Emberson… - bmj, 2019 - bmj.com
Assessment of risk of bias is regarded as an essential component of a systematic review on
the effects of an intervention. The most commonly used tool for randomised trials is the …
the effects of an intervention. The most commonly used tool for randomised trials is the …
Blood pressure lowering for prevention of cardiovascular disease and death: a systematic review and meta-analysis
…, A Kiran, SG Anderson, T Callender, J Emberson… - The Lancet, 2016 - thelancet.com
Background The benefits of blood pressure lowering treatment for prevention of cardiovascular
disease are well established. However, the extent to which these effects differ by …
disease are well established. However, the extent to which these effects differ by …
[HTML][HTML] Effect of treatment delay, age, and stroke severity on the effects of intravenous thrombolysis with alteplase for acute ischaemic stroke: a meta-analysis of …
Background Alteplase is effective for treatment of acute ischaemic stroke but debate continues
about its use after longer times since stroke onset, in older patients, and among patients …
about its use after longer times since stroke onset, in older patients, and among patients …
Association between administration of systemic corticosteroids and mortality among critically ill patients with COVID-19: a meta-analysis
…, AB Cavalcanti, PF Dequin, B Du, J Emberson… - Jama, 2020 - jamanetwork.com
Importance Effective therapies for patients with coronavirus disease 2019 (COVID-19) are
needed, and clinical trial data have demonstrated that low-dose dexamethasone reduced …
needed, and clinical trial data have demonstrated that low-dose dexamethasone reduced …
[HTML][HTML] Efficacy and safety of statin therapy in older people: a meta-analysis of individual participant data from 28 randomised controlled trials
…, J de Lemos, JR Downs, P Durrington, J Emberson… - The Lancet, 2019 - thelancet.com
Background Statin therapy has been shown to reduce major vascular events and vascular
mortality in a wide range of individuals, but there is uncertainty about its efficacy and safety …
mortality in a wide range of individuals, but there is uncertainty about its efficacy and safety …
Effect of dexamethasone in hospitalized patients with COVID-19–preliminary report
Background Coronavirus disease 2019 (COVID-19) is associated with diffuse lung damage.
Corticosteroids may modulate immune-mediated lung injury and reducing progression to …
Corticosteroids may modulate immune-mediated lung injury and reducing progression to …
Aspirin in the primary and secondary prevention of vascular disease: collaborative meta-analysis of individual participant data from randomised trials.
C Baigent, L Blackwell, R Collins, J Emberson… - …, 2009 - researchonline.lshtm.ac.uk
BACKGROUND: Low-dose aspirin is of definite and substantial net benefit for many people
who already have occlusive vascular disease. We have assessed the benefits and risks in …
who already have occlusive vascular disease. We have assessed the benefits and risks in …
Do selective cyclo-oxygenase-2 inhibitors and traditional non-steroidal anti-inflammatory drugs increase the risk of atherothrombosis? Meta-analysis of randomised …
Objective To assess the effects of selective cyclo-oxygenase-2 (COX 2) inhibitors and traditional
non-steroidal anti-inflammatory drugs (NSAIDs) on the risk of vascular events. Design …
non-steroidal anti-inflammatory drugs (NSAIDs) on the risk of vascular events. Design …
[HTML][HTML] The effects of lowering LDL cholesterol with statin therapy in people at low risk of vascular disease: meta-analysis of individual data from 27 randomised trials.
B Mihaylova, J Emberson, L Blackwell… - Lancet (London …, 2012 - europepmc.org
Background Statins reduce LDL cholesterol and prevent vascular events, but their net
effects in people at low risk of vascular events remain uncertain. Methods This meta-analysis …
effects in people at low risk of vascular events remain uncertain. Methods This meta-analysis …