Recent advances in 3D culture systems have led to the generation of brain organoids that
resemble different human brain regions; however, a 3D organoid model of the midbrain …

RNA modifications, such as N 6 -methyladenosine (m 6 A), modulate functions of cellular
RNA species. However, quantifying differences in RNA modifications has been challenging. …

Human endogenous retrovirus subfamily H (HERVH) is a class of transposable elements
expressed preferentially in human embryonic stem cells (hESCs). Here, we report that the long …

The rapid growth of high-throughput technologies has transformed biomedical research. With
the increasing amount and complexity of data, scalability and reproducibility have become …

About half of the human genome consists of highly repetitive elements, most of which are
considered dispensable for human life. Here, we report that repetitive elements originating …

X-linked intellectual disability (XLID) is a clinically and genetically heterogeneous disorder.
During the past two decades in excess of 100 X-chromosome ID genes have been identified. …

Transcript alterations often result from somatic changes in cancer genomes 1 . Various forms
of RNA alterations have been described in cancer, including overexpression 2 , altered …

Most approaches to transcript quantification rely on fixed reference annotations; however,
the transcriptome is dynamic and depending on the context, such static annotations contain …

RNA modifications such as m6A methylation form an additional layer of complexity in the
transcriptome. Nanopore direct RNA sequencing can capture this information in the raw current …

Vinyl chloride (VC) is a human carcinogen and widespread priority pollutant. Here we report
the first, to our knowledge, complete genome sequences of microorganisms able to respire …