Poly[adenosine diphosphate (ADP)–ribose] polymerases (PARPs) are a family of enzymes
that modulate diverse biological processes through covalent transfer of ADP-ribose from the …

SARS-CoV-2 is the viral pathogen causing the COVID19 global pandemic. Consequently,
much research has gone into the development of preclinical assays for the discovery of new …

Adult liver malignancies, including intrahepatic cholangiocarcinoma and hepatocellular
carcinoma, are the second leading cause of cancer-related deaths worldwide. Most individuals …

Many compounds with potentially reactive chemical motifs and poor physicochemical properties
are published as selective modulators of biomolecules without sufficient validation and …

The National Center for Advancing Translational Sciences (NCATS) has developed an online
open science data portal for its COVID-19 drug repurposing campaign–named OpenData–…

The reliance of many cancers on aerobic glycolysis has stimulated efforts to develop lactate
dehydrogenase (LDH) inhibitors. However, despite significant efforts, LDH inhibitors (LDHi) …

Mammalian sirtuin 6 (SIRT6) exhibits many pivotal functions and multiple enzymatic activities,
but the contribution of each activity to the various functions is unclear. We identified a …

Non-enzymatic protein modification driven by thioester reactivity is thought to play a major
role in the establishment of cellular lysine acylation. However, the specific protein targets of …

Hereditary cancer disorders often provide an important window into novel mechanisms
supporting tumor growth. Understanding these mechanisms thus represents a vital goal. Toward …

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has prompted
researchers to pivot their efforts to finding antiviral compounds and vaccines. In this study, …