During development, erythroid cells are produced through at least 2 distinct hematopoietic
waves (primitive and definitive), generating erythroblasts with different functional …

Tissue damage elicits cell fate switching through a process called metaplasia, but how the
starting cell fate is silenced and the new cell fate is activated has not been investigated in …

The importance of diversity is self-evident in medicine and medical research. Not only does
diversity result in more impactful scientific work, but diverse teams of researchers and …

Oncogenes can create metabolic vulnerabilities in cancer cells. We tested how AKT (herein
referring to AKT1) and MYC affect the ability of cells to shift between respiration and …

Epigenetically mediated cell signaling is emerging as a core principle of tumor biology. Through
single cell multi-omic profiling, Burdziak, Alonso-Curbelo et al. have recently uncovered …

Malignant gliomas are incurable brain neoplasms with dismal prognoses and near-universal
fatality, with minimal therapeutic progress despite billions of dollars invested in research …

Diffuse gliomas are epigenetically dysregulated, immunologically cold, and fatal tumors
characterized by mutations in isocitrate dehydrogenase (IDH). Although IDH mutations yield a …

The classification of medical devices by the Food and Drug Administration (FDA) involves
rigorous scrutiny from specialized panels that designate devices as Class I, II, or III depending …

Pediatric high-grade glioma (pHGG) is an incurable central nervous system malignancy that
is a leading cause of pediatric cancer death. While pHGG shares many similarities to adult …

Adult liver malignancies, including intrahepatic cholangiocarcinoma and hepatocellular
carcinoma, are the second leading cause of cancer-related deaths worldwide. Most individuals …