Nondestructive tissue analysis for ex vivo and in vivo cancer diagnosis using a handheld mass spectrometry system

J Zhang, J Rector, JQ Lin, JH Young, M Sans… - Science translational …, 2017 - science.org
Conventional methods for histopathologic tissue diagnosis are labor- and time-intensive
and can delay decision-making during diagnostic and therapeutic procedures. We report the …

Efforts to make and apply humanized yeast

JM Laurent, JH Young, AH Kachroo… - Briefings in functional …, 2016 - academic.oup.com
Despite a billion years of divergent evolution, the baker’s yeast Saccharomyces cerevisiae
has long proven to be an invaluable model organism for studying human biology. Given its …

Metabolic markers and statistical prediction of serous ovarian cancer aggressiveness by ambient ionization mass spectrometry imaging

…, R Tibshirani, J Zhang, L Liang, J Liu, JH Young… - Cancer research, 2017 - AACR
Ovarian high-grade serous carcinoma (HGSC) results in the highest mortality among
gynecological cancers, developing rapidly and aggressively. Dissimilarly, serous borderline …

Genome-wide association meta-analysis in 269,867 individuals identifies new genetic and functional links to intelligence

…, M Nygaard, CA Reynolds, JW Trampush, H Young… - Nature …, 2018 - nature.com
Intelligence is highly heritable 1 and a major determinant of human health and well-being 2
. Recent genome-wide meta-analyses have identified 24 genomic loci linked to variation in …

[HTML][HTML] Genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1

…, K Wolk, N Wood, J Worthington, HS Young… - Nature …, 2010 - ncbi.nlm.nih.gov
(WTCCC2) consortia is provided in the Supplementary Note online. Author Contributions FC,
ADB, CEMG, J. Kere., A. Reis, JNB and RCT oversaw cohort collection for both the …

[HTML][HTML] A scalable system for production of functional pancreatic progenitors from human embryonic stem cells

TC Schulz, HY Young, AD Agulnick, MJ Babin… - PloS one, 2012 - journals.plos.org
Development of a human embryonic stem cell (hESC)-based therapy for type 1 diabetes will
require the translation of proof-of-principle concepts into a scalable, controlled, and …

Contagion in financial networks

P Glasserman, HP Young - Journal of Economic Literature, 2016 - aeaweb.org
The recent financial crisis has prompted much new research on the interconnectedness of the
modern financial system and the extent to which it contributes to systemic fragility. Network …

The evolution of social norms

HP Young - economics, 2015 - annualreviews.org
… do not interact, or interact only occasionally, they may follow different evolutionary trajectories
and thus have different norms even though in other respects they are similar (Young 1998b…

[HTML][HTML] Interaction between genetic control of vascular endothelial growth factor production and retinoid responsiveness in psoriasis

HS Young, AM Summers, IR Read, DA Fairhurst… - Journal of investigative …, 2006 - Elsevier
Vascular endothelial growth factor (VEGF) promotes angiogenesis, and elevated levels are
found in plaques of psoriasis. Two VEGF polymorphisms, +405 and −460, are associated …

Patterns, causes, and consequences of anthropocene defaunation

HS Young, DJ McCauley, M Galetti… - Annual review of …, 2016 - annualreviews.org
Anthropocene defaunation, the global extinction of faunal species and populations and the
decline in abundance of individuals within populations, has been predominantly documented …