User profiles for Jonathan L. Braff
 | Jonathan BraffHarvard Medical School: Wyss Institute Verified email at wyss.harvard.edu Cited by 2669 |
Highly efficient Cas9-mediated transcriptional programming
…, DJ Wiegand, D Ter-Ovanesyan, JL Braff… - Nature …, 2015 - nature.com
The RNA-guided nuclease Cas9 can be reengineered as a programmable transcription
factor. However, modest levels of gene activation have limited potential applications. We …
factor. However, modest levels of gene activation have limited potential applications. We …
Orthogonal Cas9 proteins for RNA-guided gene regulation and editing
The Cas9 protein from the Streptococcus pyogenes CRISPR-Cas acquired immune system
has been adapted for both RNA-guided genome editing and gene regulation in a variety of …
has been adapted for both RNA-guided genome editing and gene regulation in a variety of …
Improving microbial fitness in the mammalian gut by in vivo temporal functional metagenomics
Elucidating functions of commensal microbial genes in the mammalian gut is challenging
because many commensals are recalcitrant to laboratory cultivation and genetic manipulation. …
because many commensals are recalcitrant to laboratory cultivation and genetic manipulation. …
Characterization of Cas9–guide RNA orthologs
In light of the multitude of new Cas9-mediated functionalities, the ability to carry out multiple
Cas9-enabled processes simultaneously and in a single cell is becoming increasingly …
Cas9-enabled processes simultaneously and in a single cell is becoming increasingly …
Characterizing Cas9 protospacer-adjacent motifs with high-throughput sequencing of library depletion experiments
This protocol outlines a general approach for characterizing the protospacer-adjacent motifs
(PAMs) of Cas9 orthologs. It uses a three-plasmid system: One plasmid carries Cas9 and its …
(PAMs) of Cas9 orthologs. It uses a three-plasmid system: One plasmid carries Cas9 and its …
[HTML][HTML] Dissecting the shared genetic architecture of suicide attempt, psychiatric disorders, and known risk factors
Background Suicide is a leading cause of death worldwide, and nonfatal suicide attempts,
which occur far more frequently, are a major source of disability and social and economic …
which occur far more frequently, are a major source of disability and social and economic …
GWAS meta-analysis of suicide attempt: identification of 12 genome-wide significant loci and implication of genetic risks for specific health factors
Objective: Suicidal behavior is heritable and is a major cause of death worldwide. Two large-scale
genome-wide association studies (GWASs) recently discovered and cross-validated …
genome-wide association studies (GWASs) recently discovered and cross-validated …
Genome-wide association study meta-analysis of suicide attempt identifies twelve genome-wide significant loci and implicates genetic risks for specific health factors
Objective Suicidal behavior is heritable and a major cause of death worldwide. Two large-scale
genome-wide association studies (GWAS) recently discovered and cross-validated …
genome-wide association studies (GWAS) recently discovered and cross-validated …
Effects of olanzapine, risperidone and haloperidol on prepulse inhibition in schizophrenia patients: a double-blind, randomized controlled trial
Prepulse inhibition (PPI), whereby the startle eyeblink response is inhibited by a relatively
weak non-startling stimulus preceding the powerful startle eliciting stimulus, is a measure of …
weak non-startling stimulus preceding the powerful startle eliciting stimulus, is a measure of …
Visual masking as a probe for abnormal gamma range activity in schizophrenia
…, KH Nuechterlein, B Breitmeyer, GA Light, DL Braff - Biological …, 2003 - Elsevier
BACKGROUND: Visual masking procedures assess very early stages of visual perception.
Patients with schizophrenia consistently show deficits on visual masking tasks, and these …
Patients with schizophrenia consistently show deficits on visual masking tasks, and these …