User profiles for Jonathan M Blackburn
J BlackburnUniversity of Cape Town Verified email at uct.ac.za Cited by 6232 |
[HTML][HTML] Omicron extensively but incompletely escapes Pfizer BNT162b2 neutralization
…, Z Jule, K Reedoy, SH Hwa, J Giandhari, JM Blackburn… - Nature, 2022 - nature.com
The emergence of the SARS-CoV-2 variant of concern Omicron (Pango lineage B.1.1.529),
first identified in Botswana and South Africa, may compromise vaccine effectiveness and …
first identified in Botswana and South Africa, may compromise vaccine effectiveness and …
[HTML][HTML] SARS-CoV-2 Omicron has extensive but incomplete escape of Pfizer BNT162b2 elicited neutralization and requires ACE2 for infection
…, Z Jule, K Reedoy, SH Hwa, J Giandhari, JM Blackburn… - MedRxiv, 2021 - ncbi.nlm.nih.gov
The emergence of SARS-CoV-2 Omicron, first identified in Botswana and South Africa, may
compromise vaccine effectiveness and the ability of antibodies triggered by previous …
compromise vaccine effectiveness and the ability of antibodies triggered by previous …
User‐friendly algorithms for estimating completeness and diversity in randomized protein‐encoding libraries
Directed evolution of proteins depends on the production of molecular diversity by random
mutagenesis. While a number of methods have been developed for introducing this diversity, …
mutagenesis. While a number of methods have been developed for introducing this diversity, …
[HTML][HTML] Quantitative Profiling of Colorectal Cancer-Associated Bacteria Reveals Associations between Fusobacterium spp., Enterotoxigenic Bacteroides fragilis …
…, A Dakshinamurthy, P Goldberg, JM Blackburn - PloS one, 2015 - journals.plos.org
Various studies have presented clinical or in vitro evidence linking bacteria to colorectal cancer,
but these bacteria have not previously been concurrently quantified by qPCR in a single …
but these bacteria have not previously been concurrently quantified by qPCR in a single …
Incorporation of glutamine repeats makes protein oligomerize: implications for neurodegenerative diseases.
K Stott, JM Blackburn, PJ Butler… - Proceedings of the …, 1995 - National Acad Sciences
Many transcription factors and some other proteins contain glutamine repeats; their abnormal
expansion has been linked to several dominantly inherited neuro-degenerative diseases. …
expansion has been linked to several dominantly inherited neuro-degenerative diseases. …
[HTML][HTML] The role of tumor microenvironment in chemoresistance: 3D extracellular matrices as accomplices
…, B Calder, NC Soares, JM Blackburn… - International journal of …, 2018 - mdpi.com
Background: The functional interplay between tumor cells and their adjacent stroma has
been suggested to play crucial roles in the initiation and progression of tumors and the …
been suggested to play crucial roles in the initiation and progression of tumors and the …
[HTML][HTML] Lactic acid from vaginal microbiota enhances cervicovaginal epithelial barrier integrity by promoting tight junction protein expression
…, S Dabee, S Barnabas, H Gamieldien, JM Blackburn… - Microbiome, 2022 - Springer
Background Women with a cervicovaginal microbiota dominated by Lactobacillus spp. are
at reduced risk of acquiring sexually transmitted infections including HIV, but the biological …
at reduced risk of acquiring sexually transmitted infections including HIV, but the biological …
Directed evolution of new catalytic activity using the α/β-barrel scaffold
In biological systems, enzymes catalyse the efficient synthesis of complex molecules under
benign conditions, but widespread industrial use of these biocatalysts depends crucially on …
benign conditions, but widespread industrial use of these biocatalysts depends crucially on …
Advances in the development of human protein microarrays
JG Duarte, JM Blackburn - Expert review of proteomics, 2017 - Taylor & Francis
Introduction: High-content protein microarrays in principle enable the functional interrogation
of the human proteome in a broad range of applications, including biomarker discovery, …
of the human proteome in a broad range of applications, including biomarker discovery, …
Citrate-capped silver nanoparticles as a probe for sensitive and selective colorimetric and spectrophotometric sensing of creatinine in human urine
…, L Karamchand, NR Hendricks, JM Blackburn - Analytica Chimica …, 2018 - Elsevier
Urinary creatinine concentration is a critical physiological parameter that enables reliable
assessment of patient renal function and diagnosis of a broad spectrum of diseases. In this …
assessment of patient renal function and diagnosis of a broad spectrum of diseases. In this …