[HTML][HTML] Mitochondrial CaMKII causes adverse metabolic reprogramming and dilated cardiomyopathy
ED Luczak, Y Wu, JM Granger, MA Joiner… - Nature …, 2020 - nature.com
Despite the clear association between myocardial injury, heart failure and depressed
myocardial energetics, little is known about upstream signals responsible for remodeling …
myocardial energetics, little is known about upstream signals responsible for remodeling …
An improved reporter identifies ruxolitinib as a potent and cardioprotective CaMKII inhibitor
OE Reyes Gaido, N Pavlaki, JM Granger… - Science translational …, 2023 - science.org
Ca 2+ /calmodulin-dependent protein kinase II (CaMKII) hyperactivity causes cardiac
arrhythmias, a major source of morbidity and mortality worldwide. Despite proven benefits of …
arrhythmias, a major source of morbidity and mortality worldwide. Despite proven benefits of …
Excessive O-GlcNAcylation Causes Heart Failure and Sudden Death
Background: Heart failure is a leading cause of death worldwide and is associated with the
rising prevalence of obesity, hypertension, and diabetes. O-GlcNAcylation (the attachment of …
rising prevalence of obesity, hypertension, and diabetes. O-GlcNAcylation (the attachment of …
[HTML][HTML] Oxidized CaMKII and O-GlcNAcylation cause increased atrial fibrillation in diabetic mice by distinct mechanisms
Diabetes mellitus (DM) and atrial fibrillation (AF) are major unsolved public health problems,
and diabetes is an independent risk factor for AF. However, the mechanism(s) underlying …
and diabetes is an independent risk factor for AF. However, the mechanism(s) underlying …
[HTML][HTML] CaMKII oxidation is a critical performance/disease trade-off acquired at the dawn of vertebrate evolution
…, MC Viswanathan, ID Blum, DC Do, JM Granger… - Nature …, 2021 - nature.com
Antagonistic pleiotropy is a foundational theory that predicts aging-related diseases are the
result of evolved genetic traits conferring advantages early in life. Here we examine CaMKII, …
result of evolved genetic traits conferring advantages early in life. Here we examine CaMKII, …
[HTML][HTML] MICAL1 constrains cardiac stress responses and protects against disease by oxidizing CaMKII
…, MC Viswanathan, ID Blum, JM Granger… - The Journal of …, 2020 - Am Soc Clin Investig
Oxidant stress can contribute to health and disease. Here we show that invertebrates and
vertebrates share a common stereospecific redox pathway that protects against pathological …
vertebrates share a common stereospecific redox pathway that protects against pathological …
[HTML][HTML] Myocardial death and dysfunction after ischemia-reperfusion injury require CaMKIIδ oxidation
Reactive oxygen species (ROS) contribute to myocardial death during ischemia-reperfusion
(I/R) injury, but detailed knowledge of molecular pathways connecting ROS to cardiac injury …
(I/R) injury, but detailed knowledge of molecular pathways connecting ROS to cardiac injury …
CaMKII exacerbates heart failure progression by activating class I HDACs
…, RJ Zimmerman, Q Wang, MA Ross, JM Granger… - Journal of molecular and …, 2020 - Elsevier
Background Persistent cardiac Ca 2+ /calmodulin dependent Kinase II (CaMKII) activation
plays an essential role in heart failure development. However, the molecular mechanisms …
plays an essential role in heart failure development. However, the molecular mechanisms …
Novel Biosensor Identifies Ruxolitinib as a Potent and Cardioprotective CaMKII Inhibitor
Ca 2+ /Calmodulin-dependent protein kinase II (CaMKII) hyperactivity causes heart injury and
arrhythmias—two major sources of mortality worldwide. Despite proven benefits of CaMKII …
arrhythmias—two major sources of mortality worldwide. Despite proven benefits of CaMKII …
CaMKII oxidation is a performance/disease trade-off in vertebrate evolution
…, MC Viswanathan, ID Blum, JM Granger… - bioRxiv, 2019 - biorxiv.org
Reactive oxygen species (ROS) contribute to health and disease. CaMKII is a widely
expressed enzyme whose activation by oxidation of regulatory domain methionines (ox-CaMKII) …
expressed enzyme whose activation by oxidation of regulatory domain methionines (ox-CaMKII) …