With the availability of high resolution structural data, increasing attention has focused on the
mechanisms by which drugs and endogenous compounds allosterically modulate nicotinic …

The spread of COVID-19 has been exacerbated by the emergence of variants of concern (VoC).
Many VoC contain mutations in the spike protein (S-protein) and are implicated in …

Although the activity of the nicotinic acetylcholine receptor (nAChR) is exquisitely sensitive
to its membrane environment, the underlying mechanisms remain poorly defined. The …

Bacterial effector proteins are essential for the infection and proliferation of pathogenic bacteria
through manipulation of host immune response pathways. AvrA is a Salmonella effector …

The ecto‐nucleoside triphosphate diphosphohydrolases (NTPDases) are a family of enzymes
found on the cell surface and in the lumen of certain organelles, that are major regulators …

Nicotinic acetylcholine receptors mediate fast synaptic transmission by fluxing ions across
the membrane in response to neurotransmitter binding. We show here that during affinity …

… This research was performed while Jonathan Labriola held an NRC Research Associateship
award at the National Severe Storms Laboratory. Funding was provided by the Verification …

Explicit prediction of hail using numerical weather prediction models remains a significant
challenge; microphysical uncertainties and errors are a significant contributor to this challenge…

Purpose: Current clinical vitreous substitutes carry major drawbacks during patient recovery
from vitreoretinal surgery including blurred vision, risk of glaucoma, face-down posturing for …

YopJs are a family of bacterial effector proteins involved in regulating host immune response
upon infection. This family of effectors is found in a wide variety of plant and animal …