AMPK functions as an adenylate charge-regulated protein kinase
The energy sensor AMP-activated protein kinase (AMPK) is activated by metabolic stress and
restores ATP levels in cells by switching off anabolic and switching on catabolic pathways. …
restores ATP levels in cells by switching off anabolic and switching on catabolic pathways. …
[HTML][HTML] Molecular mechanisms underlying the beneficial effects of exercise on brain function and neurological disorders
As life expectancy has increased, particularly in developed countries, due to medical
advances and increased prosperity, age-related neurological diseases and mental health …
advances and increased prosperity, age-related neurological diseases and mental health …
[HTML][HTML] Identification of an intestinal heme transporter
M Shayeghi, GO Latunde-Dada, JS Oakhill, AH Laftah… - Cell, 2005 - cell.com
Dietary heme iron is an important nutritional source of iron in carnivores and omnivores that
is more readily absorbed than non-heme iron derived from vegetables and grain. Most heme …
is more readily absorbed than non-heme iron derived from vegetables and grain. Most heme …
AMPK is a direct adenylate charge-regulated protein kinase
The adenosine monophosphate (AMP)–activated protein kinase (AMPK) regulates whole-body
and cellular energy balance in response to energy demand and supply. AMPK is an αβγ …
and cellular energy balance in response to energy demand and supply. AMPK is an αβγ …
New perspectives on the role of Drp1 isoforms in regulating mitochondrial pathophysiology
Mitochondria are dynamic organelles constantly undergoing fusion and fission. A concerted
balance between the process of mitochondrial fusion and fission is required to maintain …
balance between the process of mitochondrial fusion and fission is required to maintain …
β-Subunit myristoylation is the gatekeeper for initiating metabolic stress sensing by AMP-activated protein kinase (AMPK)
JS Oakhill, ZP Chen, JW Scott, R Steel… - Proceedings of the …, 2010 - National Acad Sciences
The AMP-activated protein kinase (AMPK) is an αβγ heterotrimer that acts as a master metabolic
regulator to maintain cellular energy balance following increased energy demand and …
regulator to maintain cellular energy balance following increased energy demand and …
[PDF][PDF] Thienopyridone drugs are selective activators of AMP-activated protein kinase β1-containing complexes
…, JE Honeyman, GR Steinberg, JS Oakhill… - Chemistry & biology, 2008 - cell.com
The AMP-activated protein kinase (AMPK) is an αβγ heterotrimer that plays a pivotal role in
regulating cellular and whole-body metabolism. Activation of AMPK reverses many of the …
regulating cellular and whole-body metabolism. Activation of AMPK reverses many of the …
Metformin and salicylate synergistically activate liver AMPK, inhibit lipogenesis and improve insulin sensitivity
Metformin is the mainstay therapy for type 2 diabetes (T2D) and many patients also take
salicylate-based drugs [ie, aspirin (ASA)] for cardioprotection. Metformin and salicylate both …
salicylate-based drugs [ie, aspirin (ASA)] for cardioprotection. Metformin and salicylate both …
[HTML][HTML] Small molecule drug A-769662 and AMP synergistically activate naive AMPK independent of upstream kinase signaling
The AMP-activated protein kinase (AMPK) is a metabolic stress-sensing αβγ heterotrimer
responsible for energy homeostasis, making it a therapeutic target for metabolic diseases such …
responsible for energy homeostasis, making it a therapeutic target for metabolic diseases such …
AMPK‐independent pathways regulate skeletal muscle fatty acid oxidation
…, S Wee, ZP Chen, BJ Michell, JS Oakhill… - The Journal of …, 2008 - Wiley Online Library
The activation of AMP‐activated protein kinase (AMPK) and phosphorylation/inhibition of
acetyl‐CoA carboxylase 2 (ACC2) is believed to be the principal pathway regulating fatty acid …
acetyl‐CoA carboxylase 2 (ACC2) is believed to be the principal pathway regulating fatty acid …