MHC class II–restricted antigen presentation by plasmacytoid dendritic cells inhibits T cell–mediated autoimmunity
…, R Lissilaa, M Benkhoucha, J Skupsky… - Journal of Experimental …, 2010 - rupress.org
Although plasmacytoid dendritic cells (pDCs) express major histocompatibility complex
class II (MHCII) molecules, and can capture, process, and present antigens (Ags), direct …
class II (MHCII) molecules, and can capture, process, and present antigens (Ags), direct …
T-cell calcium dynamics visualized in a ratiometric tdTomato-GCaMP6f transgenic reporter mouse
TX Dong, S Othy, A Jairaman, J Skupsky, A Zavala… - Elife, 2017 - elifesciences.org
10.7554/eLife.32417.001 Calcium is an essential cellular messenger that regulates numerous
functions in living organisms. Here, we describe development and characterization of ‘…
functions in living organisms. Here, we describe development and characterization of ‘…
[HTML][HTML] Biotin supplementation ameliorates murine colitis by preventing NF-κB activation
J Skupsky, S Sabui, M Hwang, M Nakasaki… - Cellular and molecular …, 2020 - Elsevier
Background & Aims Biotin is a water-soluble vitamin that is indispensable for human health.
Biotin deficiency can cause failure-to-thrive, immunodeficiency, alopecia, dermatitis, and …
Biotin deficiency can cause failure-to-thrive, immunodeficiency, alopecia, dermatitis, and …
Effect of B-cell depletion using anti-CD20 therapy on inhibitory antibody formation to human FVIII in hemophilia A mice
AH Zhang, J Skupsky, DW Scott - Blood, The Journal of the …, 2011 - ashpublications.org
We herein tested the effect of B-cell depletion on tolerance induction to factor VIII (FVIII) in a
mouse model of hemophilia A. Two subclasses of anti–mouse CD20 monoclonal antibodies …
mouse model of hemophilia A. Two subclasses of anti–mouse CD20 monoclonal antibodies …
[HTML][HTML] Biotin deficiency induces intestinal dysbiosis associated with an inflammatory bowel disease-like phenotype
Biotin is an essential vitamin and critical cofactor in several metabolic pathways, and its
deficiency has been linked to several disorders including inflammatory bowel disease (IBD). We …
deficiency has been linked to several disorders including inflammatory bowel disease (IBD). We …
A role for thrombin in the initiation of the immune response to therapeutic factor VIII
J Skupsky, AH Zhang, Y Su… - Blood, The Journal of the …, 2009 - ashpublications.org
Administration of human factor VIII (FVIII) to FVIII knockout hemophilia mice is a useful small
animal model to study the physiologic response in patients iatrogenically immunized to this …
animal model to study the physiologic response in patients iatrogenically immunized to this …
[HTML][HTML] B-cell-delivered gene therapy induces functional T regulatory cells and leads to a loss of antigen-specific effector cells
J Skupsky, AH Zhang, Y Su, DW Scott - Molecular Therapy, 2010 - cell.com
Previous reports have shown that B-cell-mediated gene therapy can induce tolerance in
several animal models for autoimmune diseases and inhibitory antibody formation in …
several animal models for autoimmune diseases and inhibitory antibody formation in …
Disseminated superficial actinic porokeratosis: a treatment review
H Skupsky, J Skupsky, G Goldenberg - Journal of dermatological …, 2012 - Taylor & Francis
Disseminated superficial actinic porokeratosis (DSAP) is a chronic disorder of keratinization
characterized by numerous papules and plaques distributed over sun-exposed sites. …
characterized by numerous papules and plaques distributed over sun-exposed sites. …
Tamoxifen-induced, intestinal-specific deletion of Slc5a6 in adult mice leads to spontaneous inflammation: involvement of NF-κB, NLRP3, and gut microbiota
S Sabui, J Skupsky, R Kapadia… - American Journal …, 2019 - journals.physiology.org
The sodium-dependent multivitamin transporter (SMVT; SLC5A6) is involved in intestinal
absorption of vitamin B7 (biotin). We have previously shown that mice with an embryonic …
absorption of vitamin B7 (biotin). We have previously shown that mice with an embryonic …
STAT6 controls the number of regulatory T cells in vivo, thereby regulating allergic lung inflammation
…, SP Chapoval, EP Smith, J Skupsky… - The Journal of …, 2013 - journals.aai.org
STAT6 plays a central role in IL-4–mediated allergic responses. Several studies indicate
that regulatory T cells (Tregs) can be modulated by IL-4 in vitro. We previously showed that …
that regulatory T cells (Tregs) can be modulated by IL-4 in vitro. We previously showed that …