The mitochondrial caseinolytic protease P (ClpP) plays a central role in mitochondrial protein
quality control by degrading misfolded proteins. Using genetic and chemical approaches, …

Protein-tyrosine phosphatases (PTPs), along with protein-tyrosine kinases, play key roles in
cellular signaling. All Class I PTPs contain an essential active site cysteinyl residue, which …

Zika virus (ZIKV) is a membrane enveloped Flavivirus with a positive strand RNA genome,
transmitted by Aedes mosquitoes. The geographical range of ZIKV has dramatically …

Viral replication is dependent on interactions between viral polypeptides and host proteins.
Identifying virus-host protein interactions can thus uncover unique opportunities for …

Deregulation of the RAS GTPase cycle due to mutations in the three RAS genes is commonly
associated with cancer development. Protein tyrosine phosphatase SHP2 promotes RAF-to…

Germline mutations in BRCA1 and BRCA2 (BRCA1/2) genes considerably increase breast
and ovarian cancer risk. Given that tumors with these mutations have elevated genomic …

Cancer cells bearing distinct KRAS mutations exhibit variable sensitivity to SHP2 inhibitors (SHP2i).
Here we show that cells harboring KRAS Q61H are uniquely resistant to SHP2i, and …

Key steps of viral replication take place at host cell membranes, but the detection of
membrane-associated protein-protein interactions using standard affinity-based approaches (eg …

Depolarized mitochondria can be degraded via mitophagy, a selective form of autophagy.
The RAB GTPase RAB7A was recently shown to play a key role in this process. RAB7A …

Congenital anomalies of the kidney and urinary tract (CAKUT) constitute one of the most
frequent birth defects and represent the most common cause of chronic kidney disease in the …