User profiles for Jonathan U. Peled

Jonathan U. Peled

Assistant Member, Memorial Sloan Kettering Cancer Center
Verified email at mskcc.org
Cited by 7383

[HTML][HTML] Intestinal Blautia is associated with reduced death from graft-versus-host disease

…, LC Miller, MD Docampo, JU Peled… - Biology of Blood and …, 2015 - Elsevier
The relationship between intestinal microbiota composition and acute graft-versus-host disease
(GVHD) after allogeneic blood/marrow transplantation (allo-BMT) is not well understood. …

The biochemistry of somatic hypermutation

JU Peled, FL Kuang, MD Iglesias-Ussel… - Annu. Rev …, 2008 - annualreviews.org
Affinity maturation of the humoral response is mediated by somatic hypermutation of the
immunoglobulin (Ig) genes and selection of higher-affinity B cell clones. Activation-induced …

Gut microbiome correlates of response and toxicity following anti-CD19 CAR T cell therapy

…, N Frey, RJ Brentjens, CH June, EG Pamer, JU Peled… - Nature medicine, 2022 - nature.com
Anti-CD19 chimeric antigen receptor (CAR) T cell therapy has led to unprecedented responses
in patients with high-risk hematologic malignancies. However, up to 60% of patients still …

The gut microbiota is associated with immune cell dynamics in humans

J Schluter, JU Peled, BP Taylor, KA Markey, M Smith… - Nature, 2020 - nature.com
The gut microbiota influences development 1 , 2 – 3 and homeostasis 4 , 5 , 6 – 7 of the
mammalian immune system, and is associated with human inflammatory 8 and immune …

[HTML][HTML] Microbiota as predictor of mortality in allogeneic hematopoietic-cell transplantation

JU Peled, ALC Gomes, SM Devlin… - … England Journal of …, 2020 - Mass Medical Soc
Background Relationships between microbiota composition and clinical outcomes after
allogeneic hematopoietic-cell transplantation have been described in single-center studies. …

Multi-omics analyses of radiation survivors identify radioprotective microbes and metabolites

…, X Li, LM Bohannon, AD Sung, NJ Chao, JU Peled… - Science, 2020 - science.org
INTRODUCTION The toxicity of high-dose ionizing radiation is associated with the induction
of both chronic and acute radiation syndromes that occur after partial or total body radiation …

Increased GVHD-related mortality with broad-spectrum antibiotic use after allogeneic hematopoietic stem cell transplantation in human patients and mice

Y Shono, MD Docampo, JU Peled… - Science translational …, 2016 - science.org
Intestinal bacteria may modulate the risk of infection and graft-versus-host disease (GVHD)
after allogeneic hematopoietic stem cell transplantation (allo-HSCT). Allo-HSCT recipients …

[HTML][HTML] Intestinal microbiota and relapse after hematopoietic-cell transplantation

JU Peled, SM Devlin, A Staffas, M Lumish… - Journal of Clinical …, 2017 - ncbi.nlm.nih.gov
Purpose The major causes of mortality after allogeneic hematopoietic-cell transplantation (allo-HCT)
are relapse, graft-versus-host disease (GVHD), and infection. We have reported …

Microbiota-derived lantibiotic restores resistance against vancomycin-resistant Enterococcus

…, JR Cross, S Narushima, K Honda, JU Peled… - Nature, 2019 - nature.com
Intestinal commensal bacteria can inhibit dense colonization of the gut by vancomycin-resistant
Enterococcus faecium (VRE), a leading cause of hospital-acquired infections 1 , 2 . A four…

High-resolution mycobiota analysis reveals dynamic intestinal translocation preceding invasive candidiasis

…, E Miranda, CA Veelken, SM Morjaria, JU Peled… - Nature medicine, 2020 - nature.com
The intestinal microbiota is a complex community of bacteria, archaea, viruses, protists and
fungi 1 , 2 . Although the composition of bacterial constituents has been linked to immune …