Differential fates of biomolecules delivered to target cells via extracellular vesicles

M Kanada, MH Bachmann, JW Hardy… - Proceedings of the …, 2015 - National Acad Sciences
Extracellular vesicles (EVs), specifically exosomes and microvesicles (MVs), are presumed
to play key roles in cell–cell communication via transfer of biomolecules between cells. The …

Charge-altering releasable transporters (CARTs) for the delivery and release of mRNA in living animals

…, JR Vargas, TR Blake, JW Hardy… - Proceedings of the …, 2017 - National Acad Sciences
Functional delivery of mRNA to tissues in the body is key to implementing fundamentally new
and potentially transformative strategies for vaccination, protein replacement therapy, and …

Efficacy of antimicrobial peptoids against Mycobacterium tuberculosis

R Kapoor, PR Eimerman, JW Hardy… - Antimicrobial agents …, 2011 - Am Soc Microbiol
Tuberculosis is a leading cause of death worldwide. Resistance of Mycobacterium to antibiotics
can make treatments less effective in some cases. We tested selected oligopeptoids—…

Microvesicle-mediated delivery of minicircle DNA results in effective gene-directed enzyme prodrug cancer therapy

M Kanada, BD Kim, JW Hardy, JA Ronald… - Molecular cancer …, 2019 - AACR
An emerging approach for cancer treatment employs the use of extracellular vesicles,
specifically exosomes and microvesicles, as delivery vehicles. We previously demonstrated that …

Isolation and nucleotide sequence determination of a gene encoding a heat-stable enterotoxin of Escherichia coli

SL Moseley, JW Hardy, MI Hug, P Echeverria… - Infection and …, 1983 - Am Soc Microbiol
A gene encoding a heat-stable enterotoxin (ST) from an Escherichia coli strain isolated from
a human with diarrhea was cloned and characterized by nucleotide sequence analysis. The …

Magnetic resonance imaging with T1 dispersion contrast

SE Ungersma, NI Matter, JW Hardy… - … in Medicine: An …, 2006 - Wiley Online Library
Prepolarized MRI uses pulsed magnetic fields to produce MR images by polarizing the
sample at one field strength (∼0.5 T) before imaging at a much lower field (∼50 mT). Contrast …

Unraveling the mechanisms of inhibition of silver‐doped bioactive glass–ceramic particles

…, JM Lensmire, ND Hammer, JW Hardy… - … Research Part A, 2023 - Wiley Online Library
Infections are a major concern in orthopedics. Antibacterial agents such as silver ions are of
great interest as broad‐spectrum biocides and have been incorporated into bioactive glass–…

Listeria monocytogenes infection alters the content and function of extracellular vesicles produced by trophoblast stem cells

…, KH Lee, J Altman, M Kanada, JW Hardy - Infection and …, 2022 - Am Soc Microbiol
Placental immunity is critical for fetal health during pregnancy, as invading pathogens spread
from the parental blood to the fetus through this organ. However, inflammatory responses …

The T cell STAT signaling network is reprogrammed within hours of bacteremia via secondary signals

AN Hotson, JW Hardy, MB Hale, CH Contag… - The Journal of …, 2009 - journals.aai.org
The delicate balance between protective immunity and inflammatory disease is challenged
during sepsis, a pathologic state characterized by aspects of both a hyperactive immune …

Monitoring dynamic interactions between breast cancer cells and human bone tissue in a co-culture model

CH Contag, WR Lie, MC Bammer, JW Hardy… - Molecular imaging and …, 2014 - Springer
Purpose Bone is a preferential site of breast cancer metastasis, and models are needed to
study this process at the level of the microenvironment. We have used bioluminescence …