Somatic mutations drive colorectal cancer (CRC) by disrupting gene regulatory mechanisms.
Distinct combinations of mutations can result in unique changes to regulatory mechanisms …

Background MicroRNAs (miRNAs) are important post-transcriptional gene regulators
controlling cellular lineage specification and differentiation during embryonic development, …

Crohn’s disease (CD) is a chronic inflammatory gut disorder. Molecular mechanisms underlying
the clinical heterogeneity of CD remain poorly understood. MicroRNAs (miRNAs) are …

Combinations of oncogenic mutations drive inter-tumor heterogeneity in colorectal cancer (CRC),
which promotes distinct phenotypes and affects therapeutic efficacy. We recently …

The role of individual miRNAs in small intestinal (SI) epithelial homeostasis is under-explored.
In this study, we discovered that miR-375 is among the most enriched miRNAs in …

Colorectal cancer (CRC) is the third most common cancer and second leading cause of
cancer-related death worldwide. Somatic mutations promote molecular variation across patients, …

Somatic mutations drive colorectal cancer (CRC) by disrupting gene regulatory mechanisms.
Distinct combinations of mutations can result in unique changes to regulatory mechanisms …

BACKGROUND The success of human societies depends intimately on the living components
of natural and managed systems. Although the geographical range limits of species are …

Background Mitral regurgitation ( MR ) has the potential to impede exercise capacity; it is
uncertain whether this is because of regurgitation itself or the underlying cause of valvular …

The genomic era is changing the understanding of cancer, although translation of the vast
amount of data available into decision-making algorithms is far from reality. Molecular profiling …