Sphingolipid-metabolizing enzymes control the dynamic balance of the cellular levels of
bioactive lipids, including the proapoptotic compound ceramide and the proliferative compound …

T cell large granular lymphocyte (T-LGL) leukemia features a clonal expansion of antigen-primed,
competent, cytotoxic T lymphocytes (CTL). To systematically understand signaling …

Encapsulation of imaging agents and drugs in calcium phosphate nanoparticles (CPNPs)
has potential as a nontoxic, bioresorbable vehicle for drug delivery to cells and tumors. The …

Sphingosine kinase (SK) is an oncogenic sphingolipid-metabolizing enzyme that catalyzes
the formation of the mitogenic second messenger sphingosine-1-phosphate (S1P) at the …

We have previously demonstrated that hexanoyl-d-erythro-sphingosine (C 6 -ceramide), an
anti-mitogenic cell-permeable lipid metabolite, limited vascular smooth muscle growth by …

Sphingosine kinase 1 (SphK1) is an oncoprotein capable of directly transforming cells and
is associated with resistance to chemotherapy and radiotherapy. SphK1 is increased in …

The sphingolipid metabolic pathway represents a potential source of new therapeutic targets
for numerous hyperproliferative/inflammatory diseases. Targets such as the sphingosine …

Sphingosine kinase 1 (Sphk1) associates with early endocytic membranes during endocytosis;
however, the role of sphingosine or sphingosine-1-phosphate as the critical metabolite in …

Metastatic cancer cells show great plasticity in their migratory mechanisms. In this review
we briefly describe the signal transduction pathways associated with the ROCK and MRCK …

We previously developed SKI-178 (N′-[(1E)-1-(3,4-dimethoxyphenyl)ethylidene]-3-(4-methoxxyphenyl)-1H-pyrazole-5-carbohydrazide)
as a novel sphingosine kinase-1 (SphK1) …