Polo-like kinase (Plk)1 executes several essential functions to promote cell division. These
functions range from centrosome maturation in late G2 phase to the regulation of cytokinesis, …

We investigated genome folding across the eukaryotic tree of life. We find two types of three-dimensional
(3D) genome architectures at the chromosome scale. Each type appears and …

Chromosome segregation errors are an important source of genomic diversification that
promote tumor heterogeneity and evolution. However, the aneuploidy induced by chromosome …

The presence of an abnormal karyotype has been shown to be profoundly detrimental at the
cellular and organismal levels but is an overt hallmark of cancer. Aneuploidy can lead to …

Cytoplasmic dynein is a large minus end–directed motor complex with multiple functions
during cell division. The dynein complex interacts with various adaptor proteins, including the …

The microtubule motor protein kinesin‐5 (Eg5) provides an outward force on centrosomes,
which drives bipolar spindle assembly. Acute inhibition of Eg5 blocks centrosome separation …

During mitosis, kinetochores need to attach to microtubules emanating from spindle poles.
Several protein complexes have been shown to mediate the kinetochore-microtubule …

Advances in genome sequencing have revealed a type of extrachromosomal DNA, historically
named double minutes (also referred to as ecDNA), to be common in a wide range of …

DNA in micronuclei is likely to get damaged. When shattered DNA from micronuclei gets
reincorporated into the primary nucleus, aberrant rearrangements can take place, a …

The spindle assembly checkpoint (SAC) ensures faithful segregation of chromosomes. Although
most mammalian cell types depend on the SAC for viability, we found that human HAP1 …