Acute myeloid leukemia (AML) associated translocations often cause gene fusions that
encode oncofusion proteins. Although many of the breakpoints involved in chromosomal …

Introduction Trained immunity refers to the memory characteristics of the innate immune system.
Memory traits of innate immunity have been reported in plants and invertebrates, as well …

Introduction Monocytes circulate in the bloodstream for up to 3 to 5 days. Concomitantly,
immunological imprinting of either tolerance (immunosuppression) or trained immunity (innate …

Methylation of position-specific lysine residues in histone N termini is a central modification
for regulating epigenetic transitions in chromatin. Each methylatable lysine residue can exist …

Many common variants have been associated with hematological traits, but identification of
causal genes and pathways has proven challenging. We performed a genome-wide …

Immunological memory in vertebrates is often exclusively attributed to T and B cell function.
Recently it was proposed that the enhanced and sustained innate immune responses …

Histone lysine methylation has been shown to index silenced chromatin regions at, for
example, pericentric heterochromatin or of the inactive X chromosome. Here, we examined the …

Characterizing the multifaceted contribution of genetic and epigenetic factors to disease
phenotypes is a major challenge in human genetics and medicine. We carried out high-…

Innate immune memory is the phenomenon whereby innate immune cells such as
monocytes or macrophages undergo functional reprogramming after exposure to microbial …

The International Human Epigenome Consortium (IHEC) coordinates the generation of a
catalog of high-resolution reference epigenomes of major primary human cell types. The …