The heart hypertrophies in response to developmental signals as well as increased workload.
Although adult-onset hypertrophy can ultimately lead to disease, cardiac hypertrophy is …

Cardiovascular disease is the number one cause of mortality in the Western world. The
heart responds to many cardiopathological conditions with hypertrophic growth by enlarging …

Cardiac regeneration is a rapidly evolving and controversial field of research. The identification
some 12 years ago of progenitor cells that reside within the heart spurred enthusiasm for …

Background— Inflammatory mechanisms have been proposed to be important in heart failure
(HF), and cytokines have been implicated to add to the progression of HF. However, it is …

If and how the heart regenerates after an injury event is highly debated. c-kit-expressing
cardiac progenitor cells have been reported as the primary source for generation of new …

This study evaluated common clinical characteristics of patients with lamin A/C gene
mutations that cause either isolated dilated cardiomyopathy or dilated cardiomyopathy in …

To the Editor: Lamin A/C gene mutations are associated with various disorders, 1 , 2 including
cardiac abnormalities characterized by atrial fibrillation, conduction-system disturbances, …

Mitochondrial calcium ( m Ca 2+ ) has a central role in both metabolic regulation and cell
death signalling, however its role in homeostatic function and disease is controversial 1 . …

Background: N 6 -Methyladenosine (m6A) methylation is the most prevalent internal
posttranscriptional modification on mammalian mRNA. The role of m6A mRNA methylation in the …

Rationale: The initial hypertrophy response to cardiac pressure overload is considered
compensatory, but with sustained stress, it eventually leads to heart failure. Recently, a role for …