Covalent ligand screening uncovers a RNF4 E3 ligase recruiter for targeted protein degradation applications
Targeted protein degradation has arisen as a powerful strategy for drug discovery allowing
the targeting of undruggable proteins for proteasomal degradation. This approach most often …
the targeting of undruggable proteins for proteasomal degradation. This approach most often …
NHS-esters as versatile reactivity-based probes for mapping proteome-wide ligandable hotspots
Most of the proteome is considered undruggable, oftentimes hindering translational efforts
for drug discovery. Identifying previously unknown druggable hotspots in proteins would …
for drug discovery. Identifying previously unknown druggable hotspots in proteins would …
[PDF][PDF] Covalent ligand discovery against druggable hotspots targeted by anti-cancer natural products
…, TR Huffman, DK Miyamoto, JI Kleinman… - Cell chemical …, 2017 - cell.com
Many natural products that show therapeutic activities are often difficult to synthesize or isolate
and have unknown targets, hindering their development as drugs. Identifying druggable …
and have unknown targets, hindering their development as drugs. Identifying druggable …
The Lancet Commission on global mental health and sustainable development
…, MM Herzallah, Y Huang, MJD Jordans, A Kleinman… - The lancet, 2018 - thelancet.com
The Sustainable Development Goals (SDGs) represent an exponential advance from the
Millennium Development Goals, with a substantially broader agenda affecting all nations and …
Millennium Development Goals, with a substantially broader agenda affecting all nations and …
The 2.5 m telescope of the sloan digital sky survey
…, E Kinney, M Klaene, SJ Kleinman… - The Astronomical …, 2006 - iopscience.iop.org
We describe the design, construction, and performance of the Sloan Digital Sky Survey
telescope located at Apache Point Observatory. The telescope is a modified two-corrector Ritchey…
telescope located at Apache Point Observatory. The telescope is a modified two-corrector Ritchey…
SEGUE: A Spectroscopic Survey of 240,000 Stars with g= 14–20
…, JE Gunn, C Jordan, W Jordan… - The Astronomical …, 2009 - iopscience.iop.org
The Sloan Extension for Galactic Understanding and Exploration (SEGUE) Survey obtained≈
240,000 moderate-resolution (R∼ 1800) spectra from 3900 Å to 9000 Å of fainter Milky …
240,000 moderate-resolution (R∼ 1800) spectra from 3900 Å to 9000 Å of fainter Milky …
The first data release of the sloan digital sky survey
…, DE Johnston, B Jordan, WP Jordan… - The Astronomical …, 2003 - iopscience.iop.org
The Sloan Digital Sky Survey (SDSS) has validated and made publicly available its First
Data Release. This consists of 2099 deg 2 of five-band (u, g, r, i, z) imaging data, 186,240 …
Data Release. This consists of 2099 deg 2 of five-band (u, g, r, i, z) imaging data, 186,240 …
New white dwarf stars in the Sloan digital sky survey data release 10
…, D Koester, G Ourique, SJ Kleinman… - Monthly Notices of …, 2015 - academic.oup.com
We report the discovery of 9088 new spectroscopically confirmed white dwarfs and subdwarfs
in the Sloan Digital Sky Survey Data Release 10. We obtain T eff , log g and mass for …
in the Sloan Digital Sky Survey Data Release 10. We obtain T eff , log g and mass for …
Magnetic white dwarf stars in the Sloan Digital Sky Survey
…, I Pelisoli, S Jordan, SJ Kleinman… - Monthly Notices of …, 2013 - academic.oup.com
To obtain better statistics on the occurrence of magnetism among white dwarfs, we searched
the spectra of the hydrogen atmosphere white dwarf stars (DAs) in the Data Release 7 of …
the spectra of the hydrogen atmosphere white dwarf stars (DAs) in the Data Release 7 of …
Evaluating the success of phosphorus management from field to watershed
Studies have demonstrated some P loss reduction following implementation of remedial
strategies at field scales. However, there has been little coordinated evaluation of best …
strategies at field scales. However, there has been little coordinated evaluation of best …