User profiles for Jordan W. Smoller
Jordan SmollerMassachusetts General Hospital Verified email at broadinstitute.org Cited by 89822 |
[HTML][HTML] Risk of COVID-19 among front-line health-care workers and the general community: a prospective cohort study
…, CJ Sidey-Gibbons, L Slevin, JW Smoller… - The Lancet Public …, 2020 - thelancet.com
Background Data for front-line health-care workers and risk of COVID-19 are limited. We
sought to assess risk of COVID-19 among front-line health-care workers compared with the …
sought to assess risk of COVID-19 among front-line health-care workers compared with the …
Biological insights from 108 schizophrenia-associated genetic loci
…, JM Silverman, K Sim, P Slominsky, JW Smoller… - Nature, 2014 - nature.com
Schizophrenia is a highly heritable disorder. Genetic risk is conferred by a large number of
alleles, including common alleles of small effect that might be detected by genome-wide …
alleles, including common alleles of small effect that might be detected by genome-wide …
The organization of the human cerebral cortex estimated by intrinsic functional connectivity
…, JL Roffman, JW Smoller… - Journal of …, 2011 - journals.physiology.org
Abstract Information processing in the cerebral cortex involves interactions among distributed
areas. Anatomical connectivity suggests that certain areas form local hierarchical relations …
areas. Anatomical connectivity suggests that certain areas form local hierarchical relations …
Molecular genetics of attention-deficit/hyperactivity disorder
Results of behavioral genetic and molecular genetic studies have converged to suggest that
both genetic and nongenetic factors contribute to the development of attention-deficit/…
both genetic and nongenetic factors contribute to the development of attention-deficit/…
Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder
…, J Fan, G Kirov, RH Perlis, EK Green, JW Smoller… - Nature …, 2008 - nature.com
To identify susceptibility loci for bipolar disorder, we tested 1.8 million variants in 4,387 cases
and 6,209 controls and identified a region of strong association (rs10994336, P = 9.1 × 10 −…
and 6,209 controls and identified a region of strong association (rs10994336, P = 9.1 × 10 −…
Rare coding variants in ten genes confer substantial risk for schizophrenia
Rare coding variation has historically provided the most direct connections between gene
function and disease pathogenesis. By meta-analysing the whole exomes of 24,248 …
function and disease pathogenesis. By meta-analysing the whole exomes of 24,248 …
Pleiotropy in complex traits: challenges and strategies
Genome-wide association studies have identified many variants that each affects multiple
traits, particularly across autoimmune diseases, cancers and neuropsychiatric disorders, …
traits, particularly across autoimmune diseases, cancers and neuropsychiatric disorders, …
Assessing the impact of population stratification on genetic association studies
Population stratification refers to differences in allele frequencies between cases and controls
due to systematic differences in ancestry rather than association of genes with disease. It …
due to systematic differences in ancestry rather than association of genes with disease. It …
[HTML][HTML] Polygenic prediction via Bayesian regression and continuous shrinkage priors
Polygenic risk scores (PRS) have shown promise in predicting human complex traits and
diseases. Here, we present PRS-CS, a polygenic prediction method that infers posterior effect …
diseases. Here, we present PRS-CS, a polygenic prediction method that infers posterior effect …
Family, twin, and adoption studies of bipolar disorder
JW Smoller, CT Finn - … Journal of Medical Genetics Part C …, 2003 - Wiley Online Library
Family, twin, and adoption studies have been essential in defining the genetic epidemiology
of bipolar disorder over the past several decades. Family studies have documented that first…
of bipolar disorder over the past several decades. Family studies have documented that first…