User profiles for Jordan W. Smoller

Jordan Smoller

Massachusetts General Hospital
Verified email at broadinstitute.org
Cited by 89822

[HTML][HTML] Risk of COVID-19 among front-line health-care workers and the general community: a prospective cohort study

…, CJ Sidey-Gibbons, L Slevin, JW Smoller… - The Lancet Public …, 2020 - thelancet.com
Background Data for front-line health-care workers and risk of COVID-19 are limited. We
sought to assess risk of COVID-19 among front-line health-care workers compared with the …

Biological insights from 108 schizophrenia-associated genetic loci

…, JM Silverman, K Sim, P Slominsky, JW Smoller… - Nature, 2014 - nature.com
Schizophrenia is a highly heritable disorder. Genetic risk is conferred by a large number of
alleles, including common alleles of small effect that might be detected by genome-wide …

The organization of the human cerebral cortex estimated by intrinsic functional connectivity

…, JL Roffman, JW Smoller… - Journal of …, 2011 - journals.physiology.org
Abstract Information processing in the cerebral cortex involves interactions among distributed
areas. Anatomical connectivity suggests that certain areas form local hierarchical relations …

Molecular genetics of attention-deficit/hyperactivity disorder

SV Faraone, RH Perlis, AE Doyle, JW Smoller… - Biological …, 2005 - Elsevier
Results of behavioral genetic and molecular genetic studies have converged to suggest that
both genetic and nongenetic factors contribute to the development of attention-deficit/…

Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder

…, J Fan, G Kirov, RH Perlis, EK Green, JW Smoller… - Nature …, 2008 - nature.com
To identify susceptibility loci for bipolar disorder, we tested 1.8 million variants in 4,387 cases
and 6,209 controls and identified a region of strong association (rs10994336, P = 9.1 × 10 −…

Rare coding variants in ten genes confer substantial risk for schizophrenia

…, E Scolnick, LJ Scott, SI Sharp, P Sklar, JW Smoller… - Nature, 2022 - nature.com
Rare coding variation has historically provided the most direct connections between gene
function and disease pathogenesis. By meta-analysing the whole exomes of 24,248 …

Pleiotropy in complex traits: challenges and strategies

…, C Cotsapas, PH Lee, SM Purcell, JW Smoller - Nature Reviews …, 2013 - nature.com
Genome-wide association studies have identified many variants that each affects multiple
traits, particularly across autoimmune diseases, cancers and neuropsychiatric disorders, …

Assessing the impact of population stratification on genetic association studies

…, N Patterson, SB Gabriel, EJ Topol, JW Smoller… - Nature …, 2004 - nature.com
Population stratification refers to differences in allele frequencies between cases and controls
due to systematic differences in ancestry rather than association of genes with disease. It …

[HTML][HTML] Polygenic prediction via Bayesian regression and continuous shrinkage priors

T Ge, CY Chen, Y Ni, YCA Feng, JW Smoller - Nature communications, 2019 - nature.com
Polygenic risk scores (PRS) have shown promise in predicting human complex traits and
diseases. Here, we present PRS-CS, a polygenic prediction method that infers posterior effect …

Family, twin, and adoption studies of bipolar disorder

JW Smoller, CT Finn - … Journal of Medical Genetics Part C …, 2003 - Wiley Online Library
Family, twin, and adoption studies have been essential in defining the genetic epidemiology
of bipolar disorder over the past several decades. Family studies have documented that first…