The coordination of macrophage polarization is essential for the robust regenerative potential
of skeletal muscle. Repair begins with a phase mediated by inflammatory monocytes (IM) …

The robust regenerative potential of skeletal muscle is imperative for the maintenance of
tissue function across a host of potential insults including exercise, infection, and trauma. The …

Maintenance of tissue integrity in skeletal muscle requires the immunomodulatory and
regenerative functions of muscle-resident regulatory T cells (Tregs). Chronic skeletal muscle …

Toxoplasma gondii infection has proven to be an ideal model to understand the delicate
balance between protective immunity and immune-mediated pathology during infection. Lethal …

T. gondii infection has proven to be an ideal model to understand the delicate balance
between protective immunity and immune-mediated pathology during infection. Lethal infection …

Toxoplasma gondii infection has proven to be an ideal model to understand the delicate
balance between protective immunity and immune mediated pathology. Tregs are necessary for …

Methods: Monocyte-derived MΦ differentiation in response to donor materials was tested by
administration of 20x10 6 irradiated BALB/c allogeneic (H-2 d; Allo) or (B6) syngeneic (H-2 b…

Injury resolution requires a coordinated immune-mediated response executed by macrophages
(MΦs). Yet, how MΦs convert local stimuli into effective repair is poorly understood. …

Chemotherapy or targeted cancer therapies have greatly improved the treatment outcome
of patients with leukemia; however, many will ultimately die because of disease relapse and …

Monocytes differentiate into CD206+ CD301+ reparative macrophages (MΦs) that orchestrate
tissue repair in response to damage signals and cytokines. Yet, transplanting allogeneic …