Research into the paraoxonase (PON) gene family has flourished over the past few years.
In the 1970s and 1980s, only PON1 was known, and the investigations were conducted, …

Obesity is not necessarily a predisposing factor for disease. It is the handling of fat and/or
excessive energy intake that encompasses the linkage of inflammation, oxidation, and …

To maintain homeostasis under diverse metabolic conditions, it is necessary to coordinate
nutrient-sensing pathways with the immune response. This coordination requires a complex …

Many countries have seen a two-wave pattern in reported cases of coronavirus disease-19
during the 2020 pandemic, with a first wave during spring followed by the current second …

To investigate whether paracentesis could be an alternative therapy for ascites, 117 cirrhotics
with tense ascites were randomly allocated into two groups. Fifty-eight patients (group 1) …

Cancer-initiating translocations such as those associated with lymphomas require the formation
of paired DNA double-strand breaks (DSBs). Activation-induced cytidine deaminase (AID…

Background: Paraoxonase 1 (PON1) is an ester hydrolase present in serum and in the liver.
The aims of the present study were to investigate the following: (a) the relationship between …

Objective Sorafenib is the standard systemic therapy for advanced hepatocellular carcinoma
(HCC). Survival benefits of resection/local ablation for early HCC are compromised by 70% …

The dynamics of proteins in aqueous solution has been investigated through a massive
approach based on “state of the art” molecular dynamics simulations performed for all protein …

Mutations of the KRAS oncogene are predictive for resistance to treatment with antibodies
against the epithelial growth factor receptor in patients with colorectal cancer. Overcoming this …