Oilseed rape (Brassica napus L.) was formed ~7500 years ago by hybridization between B.
rapa and B. oleracea, followed by chromosome doubling, a process known as allopolyploidy…

Obesity and type 2 diabetes have a heritable component that is not attributable to genetic
factors. Instead, epigenetic mechanisms may play a role. We have developed a mouse model …

Epigenetic modifications, including DNA methylation, represent a potential mechanism for
environmental impacts on human disease. Maternal smoking in pregnancy remains an …

Pyrosequencing is a sequencing-by-synthesis method that quantitatively monitors the real-time
incorporation of nucleotides through the enzymatic conversion of released …

Background: Huge progress has been made in the development of array- or sequencing-based
technologies for DNA methylation analysis. The Illumina Infinium ® Human Methylation …

The Human Epigenome Project aims to identify, catalogue, and interpret genome-wide DNA
methylation phenomena. Occurring naturally on cytosine bases at cytosine–guanine …

Monozygotic (MZ) twin pair discordance for childhood-onset Type 1 Diabetes (T1D) is ∼50%,
implicating roles for genetic and non-genetic factors in the aetiology of this complex …

Background European cross-sectional studies have suggested that prenatal and postnatal
farm exposure decreases the risk of allergic diseases in childhood. Underlying immunologic …

Background Epicutaneous immunotherapy ( EPIT ) is a promising method for treating food
allergies. In animal models, EPIT induces sustained unresponsiveness and prevents further …

Epigenetic changes can be defined as stable molecular alterations of a cellular phenotype
such as the gene expression profile of a cell that are heritable during somatic cell divisions (…