Cytoscape is one of the most successful network biology analysis and visualization tools,
but because of its interactive nature, its role in creating reproducible, scalable, and novel …

Tissue homeostasis requires maintenance of functional integrity under stress. A central
source of stress is mechanical force that acts on cells, their nuclei, and chromatin, but how the …

Adeno-associated virus type 2 (AAV-2) targeting vectors have been generated by insertion
of ligand peptides into the viral capsid at amino acid position 587. This procedure ablates …

Survival of chronic lymphocytic leukemia (CLL) cells depends on stimuli provided by a
suitable microenvironment. The factors and mechanisms providing this growth support for CLL …

Background Genetic modification of capsid proteins by peptide insertion has created the
possibility of using adeno‐associated viral (AAV) vectors for receptor specific gene transfer (…

Growing evidence suggests a key role for RNA binding proteins (RBPs) in genome stability
programs. Additionally, recent developments in RNA sequencing technologies, as well as …

The endoplasmic reticulum (ER) coordinates mRNA translation and processing of secreted
and endomembrane proteins. ER-associated degradation (ERAD) prevents the …

In response to DNA damage, cells activate a complex, kinase-based signaling network to
arrest the cell cycle and allow time for DNA repair, or, if the extend of damage is beyond repair …

During the last decade, the study of mRNA decay has largely benefited from an increasing
number of high-throughput assays that emerged from developments in next generation …

Recent therapeutic advances in chronic lymphocytic leukemia (CLL) are reflected by high
response rates in most subsets of patients. However, refractory disease remains a problem, …