Rat cortical astrocytes in pure culture are functionally coupled to neighboring cells via connexin
(Cx) 43 gap junctions under ordinary conditions. Small fluorescent molecules such as …

Connexin 43 (Cx43) nonjunctional or “unapposed” hemichannels can open under physiological
or pathological conditions. We characterize hemichannels comprised of Cx43 or Cx43-…

Gap junctions are clusters of aqueous channels that connect the cytoplasm of adjoining cells.
Each cell contributes a hemichannel, or connexon, to each cell–cell channel. The cell–cell …

Gap junction channels and hemichannels formed of connexin subunits are found in most cell
types in vertebrates. Gap junctions connect cells via channels not open to the extracellular …

Hepatitis E virus (HEV) is the leading cause of enterically transmitted viral hepatitis globally.
Of HEV’s three ORFs, the function of ORF3 has remained elusive. Here, we demonstrate …

Gap junctions (Gj) play an important role in the communication between cells of many tissues.
They are composed of channels that permit the passage of ions and low molecular weight …

Connexin 43 (Cx43) gap junctions and hemichannels mediate astrocyte intercellular
communication in the central nervous system under normal conditions and contribute to astrocyte-…

Pannexin 1 (Panx1) is a membrane channel implicated in numerous physiological and
pathophysiological processes via its ability to support release of ATP and other cellular …

Aberrant opening of nonjunctional connexin hemichannels at the plasma membrane is
associated with many diseases, including ischemia and muscular dystrophy. Proper control of …

Mutations in Cx26 gene are found in most cases of human genetic deafness. Some
mutations produce syndromic deafness associated with skin disorders, like the Keratitis-Ichthyosis-…