Conventional two-dimensional differentiation from pluripotency fails to recapitulate cell
interactions occurring during organogenesis. Three-dimensional organoids generate complex …

INTRODUCTION Axolotls (Ambystoma mexicanum) and other salamanders are the only
tetrapods that can regenerate whole limbs. During this complex process, changes in gene …

10.7554/eLife.13546.001 Inducible epigenetic changes in eukaryotes are believed to
enable rapid adaptation to environmental fluctuations. We have found distinct regions of the …

Ectopic expression of defined transcription factors can force direct cell-fate conversion from
one lineage to another in the absence of cell division. Several transcription factor cocktails …

Objective Clinical heterogeneity, a hallmark of systemic autoimmune diseases, impedes
early diagnosis and effective treatment, issues that may be addressed if patients could be …

Engineering specific interactions between proteins and small molecules is extremely useful
for biological studies, as these interactions are essential for molecular recognition. …

Single-cell mRNA sequencing (scRNA-seq) is a powerful method to identify and classify cell
types and reconstruct differentiation trajectories within complex tissues, such as the …

Wibowo A, Becker C, Marconi G, Durr J, Price J, Hagmann J, Papareddy R, Putra H,
Kageyama J, Becker J, Weigel D, Gutierrez-Marcos J. 2016. Hyperosmotic stress memory in …

Objective Systemic Lupus Erythematosus (SLE) is a complex autoimmune disease with a
diverse pathophysiology triggered by the loss of self-tolerance, resulting in inflammation and …

The gold standard for studying natural selection is to quantify lifetime fitness in individuals
from natural populations that have been grown together under different field conditions. This …