Liquid-liquid phase separation (LLPS) mediates formation of membraneless condensates
such as those associated with RNA processing, but the rules that dictate their assembly, …

Condensin plays crucial roles in chromosome organization and compaction, but the
mechanistic basis for its functions remains obscure. We used single-molecule imaging to …

Organization of the genome into transcriptionally active euchromatin and silenced
heterochromatin is essential for eukaryotic cell function. Phase-separation has been implicated in …

The nucleolus is the largest biomolecular condensate and facilitates transcription, processing,
and assembly of ribosomal RNA (rRNA). Although nucleolar function is thought to require …

Structural maintenance of chromosomes (SMC) protein complexes, including cohesin and
condensin, play key roles in the regulation of higher-order chromosome organization. Even …

Condensin, a conserved member of the SMC protein family of ring‐shaped multi‐subunit
protein complexes, is essential for structuring and compacting chromosomes. Despite its key …

Differential diagnosis between Parkinson's disease (PD) and multiple system atrophy (MSA)
is difficult, particularly at early disease stages, but is important for therapeutic management. …

Euchromatin histone methyltransferase 1 (EHMT1) is a highly conserved protein that
catalyzes mono- and dimethylation of histone H3 lysine 9, thereby epigenetically regulating …

Background Single-molecule techniques have proven to be an excellent approach for
quantitatively studying DNA-protein interactions at the single-molecule level. In magnetic tweezers…

The nucleolus is the largest membrane-less intracellular condensate, which facilitates
transcription, processing, and assembly of ribosomal RNA (rRNA), the most abundant RNA in the …