User profiles for Joris de Wit
Joris de WitGroup Leader at VIB Center for Brain & Disease Research/KU Leuven, Department of … Verified email at cme.vib-kuleuven.be Cited by 5769 |
[HTML][HTML] Specification of synaptic connectivity by cell surface interactions
The molecular diversification of cell surface molecules has long been postulated to impart
specific surface identities on neuronal cell types. The existence of unique cell surface …
specific surface identities on neuronal cell types. The existence of unique cell surface …
[PDF][PDF] Molecular mechanisms of synaptic specificity in developing neural circuits
The function of the brain depends on highly specific patterns of connections between
populations of neurons. The establishment of these connections requires the targeting of axons …
populations of neurons. The establishment of these connections requires the targeting of axons …
Role of leucine-rich repeat proteins in the development and function of neural circuits
The nervous system consists of an ensemble of billions of neurons interconnected in a
highly specific pattern that allows proper propagation and integration of neural activities. The …
highly specific pattern that allows proper propagation and integration of neural activities. The …
Expression of the gene encoding the chemorepellent semaphorin III is induced in the fibroblast component of neural scar tissue formed following injuries of adult but …
This study evaluates the expression of the chemorepellent semaphorin III (D)/collapsin-1 (sema
III) following lesions to the rat CNS. Scar tissue, formed after penetrating injuries to the …
III) following lesions to the rat CNS. Scar tissue, formed after penetrating injuries to the …
[HTML][HTML] Tau association with synaptic vesicles causes presynaptic dysfunction
Tau is implicated in more than 20 neurodegenerative diseases, including Alzheimer’s disease.
Under pathological conditions, Tau dissociates from axonal microtubules and missorts to …
Under pathological conditions, Tau dissociates from axonal microtubules and missorts to …
Secreted amyloid-β precursor protein functions as a GABABR1a ligand to modulate synaptic transmission
INTRODUCTION More than 30 years have passed since the amyloid-β precursor protein (APP)
was identified. Although the role of APP in Alzheimer’s disease has been studied widely, …
was identified. Although the role of APP in Alzheimer’s disease has been studied widely, …
Brain-derived neurotrophic factor in the ventral midbrain–nucleus accumbens pathway: a role in depression
BACKGROUND: Previous work has shown that brain-derived neurotrophic factor (BDNF) and
its receptor, tyrosine kinase receptor B (TrkB), are involved in appetitive behavior. Here we …
its receptor, tyrosine kinase receptor B (TrkB), are involved in appetitive behavior. Here we …
[PDF][PDF] LRRTM2 interacts with Neurexin1 and regulates excitatory synapse formation
We identify the leucine-rich repeat transmembrane protein LRRTM2 as a key regulator of
excitatory synapse development and function. LRRTM2 localizes to excitatory synapses in …
excitatory synapse development and function. LRRTM2 localizes to excitatory synapses in …
[PDF][PDF] FLRT proteins are endogenous latrophilin ligands and regulate excitatory synapse development
Latrophilins (LPHNs) are a small family of G protein-coupled receptors known to mediate the
massive synaptic exocytosis caused by the black widow spider venom α-latrotoxin, but their …
massive synaptic exocytosis caused by the black widow spider venom α-latrotoxin, but their …
[PDF][PDF] Synaptic contacts enhance cell-to-cell tau pathology propagation
Accumulation of insoluble Tau protein aggregates and stereotypical propagation of Tau
pathology through the brain are common hallmarks of tauopathies, including Alzheimer's …
pathology through the brain are common hallmarks of tauopathies, including Alzheimer's …