The molecular diversification of cell surface molecules has long been postulated to impart
specific surface identities on neuronal cell types. The existence of unique cell surface …

The function of the brain depends on highly specific patterns of connections between
populations of neurons. The establishment of these connections requires the targeting of axons …

The nervous system consists of an ensemble of billions of neurons interconnected in a
highly specific pattern that allows proper propagation and integration of neural activities. The …

This study evaluates the expression of the chemorepellent semaphorin III (D)/collapsin-1 (sema
III) following lesions to the rat CNS. Scar tissue, formed after penetrating injuries to the …

Tau is implicated in more than 20 neurodegenerative diseases, including Alzheimer’s disease.
Under pathological conditions, Tau dissociates from axonal microtubules and missorts to …

INTRODUCTION More than 30 years have passed since the amyloid-β precursor protein (APP)
was identified. Although the role of APP in Alzheimer’s disease has been studied widely, …

BACKGROUND: Previous work has shown that brain-derived neurotrophic factor (BDNF) and
its receptor, tyrosine kinase receptor B (TrkB), are involved in appetitive behavior. Here we …

We identify the leucine-rich repeat transmembrane protein LRRTM2 as a key regulator of
excitatory synapse development and function. LRRTM2 localizes to excitatory synapses in …

Latrophilins (LPHNs) are a small family of G protein-coupled receptors known to mediate the
massive synaptic exocytosis caused by the black widow spider venom α-latrotoxin, but their …

Accumulation of insoluble Tau protein aggregates and stereotypical propagation of Tau
pathology through the brain are common hallmarks of tauopathies, including Alzheimer's …