Most of the millions of SNPs in the human genome are non-coding, and many overlap with
putative regulatory elements. Genome-wide association studies (GWAS) have linked many of …

Previous methods to systematically characterize sequence-intrinsic activity of promoters
have been limited by relatively low throughput and the length of the sequences that could be …

Although it was originally believed that enhancers activate only the nearest promoter, recent
global analyses enabled by high-throughput technology suggest that the network of …

It is currently not known whether dopamine (DA) neurons derived from human embryonic stem
cells (hESCs) can survive in vivo and alleviate symptoms in models of Parkinson disease (…

A significant portion of the genome is transcribed as long noncoding RNAs (lncRNAs), several
of which are known to control gene expression. The repertoire and regulation of lncRNAs …

The epigenome changes that underlie cellular differentiation in developing organisms are
poorly understood. To gain insights into how pancreatic beta-cells are programmed, we …

Gene expression is in part controlled by cis-regulatory elements (CREs) such as enhancers
and repressive elements. Anecdotal evidence has indicated that a CRE and a promoter …

It is largely unclear whether genes that are naturally embedded in lamina-associated
domains (LADs) are inactive due to their chromatin environment or whether LADs are merely …

Housekeeping genes of animal genomes cluster in the same chromosomal regions. It has
long been suggested that this organization contributes to their steady expression across all …

Dam identification (DamID) is a powerful technique to generate genome-wide maps of
chromatin protein binding. Due to its high sensitivity, it is particularly suited to study the genome …