SARS-CoV-2–triggered neutrophil extracellular traps mediate COVID-19 pathology
Severe COVID-19 patients develop acute respiratory distress syndrome that may progress
to cytokine storm syndrome, organ dysfunction, and death. Considering that neutrophil …
to cytokine storm syndrome, organ dysfunction, and death. Considering that neutrophil …
[HTML][HTML] Inflammasomes are activated in response to SARS-CoV-2 infection and are associated with COVID-19 severity in patients
…, MN Benatti, TM Cunha, JC Alves-Filho… - Journal of Experimental …, 2021 - rupress.org
Severe cases of COVID-19 are characterized by a strong inflammatory process that may
ultimately lead to organ failure and patient death. The NLRP3 inflammasome is a molecular …
ultimately lead to organ failure and patient death. The NLRP3 inflammasome is a molecular …
SRB measures for partially hyperbolic systems whose central direction is mostly expanding
We construct Sinai-Ruelle-Bowen (SRB) measures supported on partially hyperbolic sets of
diffeomorphisms – the tangent bundle splits into two invariant subbundles, one of which is …
diffeomorphisms – the tangent bundle splits into two invariant subbundles, one of which is …
Work stress and leadership development: The role of self-leadership, shared leadership, physical fitness and flow in managing demands and increasing job control
Leaders work in highly stressful environments, yet few leadership development efforts have
focused on managing work stress. We posit that self- and shared leadership practices can …
focused on managing work stress. We posit that self- and shared leadership practices can …
[HTML][HTML] Neutrophil extracellular traps induce organ damage during experimental and clinical sepsis
Organ dysfunction is a major concern in sepsis pathophysiology and contributes to its high
mortality rate. Neutrophil extracellular traps (NETs) have been implicated in endothelial …
mortality rate. Neutrophil extracellular traps (NETs) have been implicated in endothelial …
[HTML][HTML] Aminotransferase changes and acute hepatitis in patients with dengue fever: analysis of 1,585 cases
LJ Souza, JG Alves, RMR Nogueira… - Brazilian journal of …, 2004 - SciELO Brasil
INTRODUCTION: Type 3 dengue virus caused an extensive epidemic in the state of Rio de
Janeiro in summer 2002. In some of the patients, it was found in an atypical form with …
Janeiro in summer 2002. In some of the patients, it was found in an atypical form with …
Paclitaxel reduces tumor growth by reprogramming tumor-associated macrophages to an M1 profile in a TLR4-dependent manner
Paclitaxel is an antineoplastic agent widely used to treat several solid tumor types. The
primary mechanism of action of paclitaxel is based on microtubule stabilization inducing cell-…
primary mechanism of action of paclitaxel is based on microtubule stabilization inducing cell-…
Morphological, cellular, and molecular basis of brain infection in COVID-19 patients
…, RB Martins, AS Vieira, JC Alves-Filho… - Proceedings of the …, 2022 - National Acad Sciences
Although increasing evidence confirms neuropsychiatric manifestations associated mainly
with severe COVID-19 infection, long-term neuropsychiatric dysfunction (recently …
with severe COVID-19 infection, long-term neuropsychiatric dysfunction (recently …
Gasdermin D inhibition prevents multiple organ dysfunction during sepsis by blocking NET formation
Multiple organ dysfunction is the most severe outcome of sepsis progression and is highly
correlated with a worse prognosis. Excessive neutrophil extracellular traps (NETs) are critical …
correlated with a worse prognosis. Excessive neutrophil extracellular traps (NETs) are critical …
Neutrophil paralysis in sepsis
Sepsis develops when the initial host response is unable to contain the primary infection,
resulting in widespread inflammation and multiple organ dysfunction. The impairment of …
resulting in widespread inflammation and multiple organ dysfunction. The impairment of …