User profiles for José Afonso Guerra-Assunção

José Afonso Guerra-Assunção

Erasmus MC, Rotterdam, Netherlands
Verified email at erasmusmc.nl
Cited by 11377

[PDF][PDF] Meta-analysis of tumor-and T cell-intrinsic mechanisms of sensitization to checkpoint inhibition

…, E Lim, M Al Bakir, V Turati, JA Guerra-Assunção… - Cell, 2021 - cell.com
Checkpoint inhibitors (CPIs) augment adaptive immunity. Systematic pan-tumor analyses
may reveal the relative importance of tumor-cell-intrinsic and microenvironmental features …

[HTML][HTML] Mouse genomic variation and its effect on phenotypes and gene regulation

…, IJ Jackson, A Czechanski, JA Guerra-Assunção… - Nature, 2011 - nature.com
We report genome sequences of 17 inbred strains of laboratory mice and identify almost ten
times more variants than previously known. We use these genomes to explore the …

The BioMart community portal: an innovative alternative to large, centralized data repositories

…, D Goodstein, K Gray, JA Guerra-Assunção… - Nucleic acids …, 2015 - academic.oup.com
The BioMart Community Portal ( www.biomart.org ) is a community-driven effort to provide a
unified interface to biomedical databases that are distributed worldwide. The portal provides …

[HTML][HTML] A robust SNP barcode for typing Mycobacterium tuberculosis complex strains

F Coll, R McNerney, JA Guerra-Assunção… - Nature …, 2014 - nature.com
Strain-specific genomic diversity in the Mycobacterium tuberculosis complex (MTBC) is an
important factor in pathogenesis that may affect virulence, transmissibility, host response and …

[HTML][HTML] Rapid determination of anti-tuberculosis drug resistance from whole-genome sequences

…, R McNerney, MD Preston, JA Guerra-Assunção… - Genome medicine, 2015 - Springer
Mycobacterium tuberculosis drug resistance (DR) challenges effective tuberculosis disease
control. Current molecular tests examine limited numbers of mutations, and although whole …

[HTML][HTML] Genomic investigations of unexplained acute hepatitis in children

…, L Atkinson, JA Guerra-Assunção… - Nature, 2023 - nature.com
Since its first identification in Scotland, over 1,000 cases of unexplained paediatric hepatitis
in children have been reported worldwide, including 278 cases in the UK 1 . Here we report …

Recurrent mTORC1-activating RRAGC mutations in follicular lymphoma

…, S Iqbal, J Matthews, A Clear, JA Guerra-Assunção… - Nature …, 2016 - nature.com
Follicular lymphoma is an incurable B cell malignancy 1 characterized by the t(14;18)
translocation and mutations affecting the epigenome 2 , 3 . Although frequent gene mutations in …

Recurrence due to Relapse or Reinfection With Mycobacterium tuberculosis: A Whole-Genome Sequencing Approach in a Large, Population-Based Cohort With a …

JA Guerra-Assunção, RMGJ Houben… - The Journal of …, 2015 - academic.oup.com
Background. Recurrent tuberculosis is a major health burden and may be due to relapse with
the original strain or reinfection with a new strain. Methods. In a population-based study in …

[HTML][HTML] Integrated analysis of microRNA and mRNA expression and association with HIF binding reveals the complexity of microRNA expression regulation under …

…, H Choudhry, M Reczko, JA Guerra-Assunção… - Molecular cancer, 2014 - Springer
Background In mammalians, HIF is a master regulator of hypoxia gene expression through
direct binding to DNA, while its role in microRNA expression regulation, critical in the hypoxia …

Spatial heterogeneity of the T cell receptor repertoire reflects the mutational landscape in lung cancer

…, CT Hiley, E Ghorani, JA Guerra-Assunção… - Nature medicine, 2019 - nature.com
Somatic mutations together with immunoediting drive extensive heterogeneity within non-small-cell
lung cancer (NSCLC). Herein we examine heterogeneity of the T cell antigen …