User profiles for José C Alves-Filho
 | José Carlos Alves FilhoDepartment of Pharmacology, Ribeirão Preto Medical School, USP, Brazil Verified email at fmrp.usp.br Cited by 14252 |
Histamine h2 receptor signaling in the pathogenesis of sepsis: studies in a murine diabetes model
Type 1 diabetes enhances susceptibility to infection and favors the sepsis development. In
addition, diabetic mice produced higher levels of histamine in several tissues and in the blood …
addition, diabetic mice produced higher levels of histamine in several tissues and in the blood …
SARS-CoV-2–triggered neutrophil extracellular traps mediate COVID-19 pathology
Severe COVID-19 patients develop acute respiratory distress syndrome that may progress
to cytokine storm syndrome, organ dysfunction, and death. Considering that neutrophil …
to cytokine storm syndrome, organ dysfunction, and death. Considering that neutrophil …
[HTML][HTML] Neutrophil extracellular traps induce organ damage during experimental and clinical sepsis
… Competing interests: The authors declare that the co-author José Carlos Alves-Filho is
part of the editorial board of PLOS ONE. This does not alter the authors’ adherence to all the …
part of the editorial board of PLOS ONE. This does not alter the authors’ adherence to all the …
Morphological, cellular, and molecular basis of brain infection in COVID-19 patients
…, RB Martins, AS Vieira, JC Alves-Filho… - Proceedings of the …, 2022 - National Acad Sciences
Although increasing evidence confirms neuropsychiatric manifestations associated mainly
with severe COVID-19 infection, long-term neuropsychiatric dysfunction (recently …
with severe COVID-19 infection, long-term neuropsychiatric dysfunction (recently …
[HTML][HTML] Inflammasomes are activated in response to SARS-CoV-2 infection and are associated with COVID-19 severity in patients
…, MN Benatti, TM Cunha, JC Alves-Filho… - Journal of Experimental …, 2021 - rupress.org
Severe cases of COVID-19 are characterized by a strong inflammatory process that may
ultimately lead to organ failure and patient death. The NLRP3 inflammasome is a molecular …
ultimately lead to organ failure and patient death. The NLRP3 inflammasome is a molecular …
Gasdermin D inhibition prevents multiple organ dysfunction during sepsis by blocking NET formation
Multiple organ dysfunction is the most severe outcome of sepsis progression and is highly
correlated with a worse prognosis. Excessive neutrophil extracellular traps (NETs) are critical …
correlated with a worse prognosis. Excessive neutrophil extracellular traps (NETs) are critical …
PKM2 promotes Th17 cell differentiation and autoimmune inflammation by fine-tuning STAT3 activation
Th17 cell differentiation and pathogenicity depend on metabolic reprogramming inducing
shifts toward glycolysis. Here, we show that the pyruvate kinase M2 (PKM2), a glycolytic …
shifts toward glycolysis. Here, we show that the pyruvate kinase M2 (PKM2), a glycolytic …
Paclitaxel reduces tumor growth by reprogramming tumor-associated macrophages to an M1 profile in a TLR4-dependent manner
Paclitaxel is an antineoplastic agent widely used to treat several solid tumor types. The
primary mechanism of action of paclitaxel is based on microtubule stabilization inducing cell-…
primary mechanism of action of paclitaxel is based on microtubule stabilization inducing cell-…
[HTML][HTML] Paradoxical roles of the neutrophil in sepsis: protective and deleterious
Sepsis, an overwhelming inflammatory response syndrome secondary to infection, is one of
the costliest and deadliest medical conditions worldwide. Neutrophils are classically …
the costliest and deadliest medical conditions worldwide. Neutrophils are classically …
Neutrophil paralysis in sepsis
Sepsis develops when the initial host response is unable to contain the primary infection,
resulting in widespread inflammation and multiple organ dysfunction. The impairment of …
resulting in widespread inflammation and multiple organ dysfunction. The impairment of …