Background The cerebrospinal fluid (CSF) biomarkers amyloid beta 1–42, total tau, and
phosphorylated tau are used increasingly for Alzheimer's disease (AD) research and patient …

In the past 8 years, both the International Working Group (IWG) and the US National Institute
on Aging–Alzheimer's Association have contributed criteria for the diagnosis of Alzheimer's …

During the past decade, a conceptual shift occurred in the field of Alzheimer's disease (AD)
considering the disease as a continuum. Thanks to evolving biomarker research and …

Importance Cerebral amyloid-β aggregation is an early pathological event in Alzheimer
disease (AD), starting decades before dementia onset. Estimates of the prevalence of amyloid …

Background Rapid-eye-movement (REM) sleep behaviour disorder (RBD) is a parasomnia
characterised by dream-enacting behaviours related to unpleasant dreams and loss of …

With the aggressive spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2),
the death toll has risen worldwide. According to an interactive online tool that estimates …

Blood biomarkers indicating elevated amyloid-β (Aβ) pathology in preclinical Alzheimer’s
disease are needed to facilitate the initial screening process of participants in disease-…

A growing awareness about brain health and Alzheimer's disease in the general population
is leading to an increasing number of cognitively unimpaired individuals, who are …

Background We postulated that idiopathic rapid-eye-movement (REM) sleep behaviour disorder
(IRBD) represents the prodromal phase of a Lewy body disorder and that, with sufficient …

Importance Glial fibrillary acidic protein (GFAP) is a marker of reactive astrogliosis that
increases in the cerebrospinal fluid (CSF) and blood of individuals with Alzheimer disease (AD). …