Macrophage scavenger receptor 1 (MSR1), also named CD204, holds key inflammatory roles
in multiple pathophysiologic processes. Present primarily on the surface of various types …

BMDMs are a key model system to study macrophage biology in vitro. Commonly used
methods to differentiate macrophages from BM are treatment with either recombinant M-CSF or …

Thermal proteome profiling (TPP) provides a powerful approach to studying proteome-wide
interactions of small therapeutic molecules and their target and off-target proteins, …

CYLD lysine 63 deubiquitinase (CYLD) is a ubiquitin hydrolase with important roles in immunity
and cancer. Complete CYLD ablation, truncation and expression of alternate isoforms, …

FADD was initially described as an adaptor molecule for death receptor-mediated apoptosis,
but subsequently it has been implicated in nonapoptotic cellular processes such as …

Phagocytosis is a key process in innate immunity and homeostasis. After particle uptake,
newly formed phagosomes mature by acquisition of endolysosomal enzymes. Macrophage …

Ubiquitylation is an elaborate post-translational modification involved in all biological
processes. Its pleotropic effect is driven by the ability to form complex polyubiquitin chain …

Inflammatory responses are important in cancer, particularly in the context of monocyte-rich
aggressive myeloid neoplasm. We developed a label-free cellular phenotypic drug discovery …

T-cell lymphoblastic lymphoma is a haematological disease with an urgent need for reliable
prognostic biomarkers that allow therapeutic stratification and dose adjustment. The scarcity …

Despite the Janus kinase/signal transducers and activators of transcription (JAK/STAT)
pathway being frequently altered in T‐ALL/LBL, no specific therapy has been approved for T‐ALL/…