While autism spectrum disorder affects nearly 2% of children in the United States, little is
known with certainty concerning the etiologies and brain systems involved. This is due, in part, …

Most autosomal genes in the placenta show a biallelic expression pattern. However, some
genes exhibit allele-specific transcription depending on the parental origin of the …

Background Zebrafish have practical features that make them a useful model for higher-throughput
tests of gene function using CRISPR/Cas9 editing to create ‘knockout’ models. In …

Structural variants (SVs)—including duplications, deletions, and inversions of DNA—can
have significant genomic and functional impacts but are technically difficult to identify and …

In recent years, zebrafish have become commonly used as a model for studying human traits
and disorders. Their small size, high fecundity, and rapid development allow for more high-…

African American women are disproportionately affected by type 2 diabetes. Genetic factors
may explain part of the excess risk. More than 100 genetic variants have been associated …

The placenta is a temporary organ that is essential for the survival of the fetus, with a lifelong
effect on the health of both the offspring and the dam. The functions of the placenta are …

Among autistic individuals, a subphenotype with brain enlargement disproportionate to height
(autism with disproportionate megalencephaly, or ASD-DM) seen at three years of age is …

Zebrafish have practical features that make them a useful model for higher-throughput tests
of gene function using CRISPR/Cas9 editing to create ‘knockout’ models. Due to the large …

In recent years, zebrafish have become commonly used as a model for studying human traits
and disorders. Their small size, high fecundity, and rapid development allow for more high-…