User profiles for Jose Antonio Enriquez
José Antonio EnríquezCentro Nacional de Investigaciones Cardiovasculares (CNIC) Verified email at cnic.es Cited by 20991 |
Supercomplex assembly determines electron flux in the mitochondrial electron transport chain
…, P Fernández-Silva, E Fernández-Vizarra, JA Enríquez - Science, 2013 - science.org
The textbook description of mitochondrial respiratory complexes (RCs) views them as free-moving
entities linked by the mobile carriers coenzyme Q (CoQ) and cytochrome c (cyt c). This …
entities linked by the mobile carriers coenzyme Q (CoQ) and cytochrome c (cyt c). This …
[PDF][PDF] NDUFA4 is a subunit of complex IV of the mammalian electron transport chain
…, R Szklarczyk, E Calvo, MO Landázuri, JA Enríquez - Cell metabolism, 2012 - cell.com
The oxidative phosphorylation system is one of the best-characterized metabolic pathways.
In mammals, the protein components and X-ray structures are defined for all complexes …
In mammals, the protein components and X-ray structures are defined for all complexes …
Oxidative phosphorylation selectively orchestrates tissue macrophage homeostasis
In vitro studies have associated oxidative phosphorylation (OXPHOS) with anti-inflammatory
macrophages, whereas pro-inflammatory macrophages rely on glycolysis. However, the …
macrophages, whereas pro-inflammatory macrophages rely on glycolysis. However, the …
[PDF][PDF] Respiratory active mitochondrial supercomplexes
…, ML Peleato, A Pérez-Martos, JA Enriquez - Molecular cell, 2008 - cell.com
The structural organization of the mitochondrial respiratory complexes as four big independently
moving entities connected by the mobile carriers CoQ and cytochrome c has been …
moving entities connected by the mobile carriers CoQ and cytochrome c has been …
[PDF][PDF] Induction of the mitochondrial NDUFA4L2 protein by HIF-1α decreases oxygen consumption by inhibiting Complex I activity
The fine regulation of mitochondrial function has proved to be an essential metabolic adaptation
to fluctuations in oxygen availability. During hypoxia, cells activate an anaerobic switch …
to fluctuations in oxygen availability. During hypoxia, cells activate an anaerobic switch …
Multifaceted mitochondria: moving mitochondrial science beyond function and dysfunction
Mitochondria have cell-type specific phenotypes, perform dozens of interconnected
functions and undergo dynamic and often reversible physiological recalibrations. Given their …
functions and undergo dynamic and often reversible physiological recalibrations. Given their …
MtDNA mutation in MERRF syndrome causes defective aminoacylation of tRNALys and premature translation termination
JA Enriquez, A Chomyn, G Attardi - Nature genetics, 1995 - nature.com
We have investigated the pathogenetic mechanism of the mitochondrial tRNA Lys gene
mutation (position 8344) associated with MERRF encephalomyopathy in several mitochondrial …
mutation (position 8344) associated with MERRF encephalomyopathy in several mitochondrial …
[PDF][PDF] Mutations of SURF-1 in Leigh disease associated with cytochrome c oxidase deficiency
…, M Rocchi, MP Bayona-Bafaluy, JA Enriquez… - The American Journal of …, 1998 - cell.com
Leigh disease associated with cytochrome c oxidase deficiency (LD [COX−] ) is one of the
most common disorders of the mitochondrial respiratory chain, in infancy and childhood. No …
most common disorders of the mitochondrial respiratory chain, in infancy and childhood. No …
Supramolecular organization of respiratory complexes
JA Enríquez - Annual Review of Physiology, 2016 - annualreviews.org
Since the discovery of the existence of superassemblies between mitochondrial respiratory
complexes, such superassemblies have been the object of a passionate debate. It is …
complexes, such superassemblies have been the object of a passionate debate. It is …
[PDF][PDF] ER and nutrient stress promote assembly of respiratory chain supercomplexes through the PERK-eIF2α axis
…, M Jedrychowski, SP Gygi, JA Enriquez… - Molecular cell, 2019 - cell.com
Endoplasmic reticulum (ER) stress and unfolded protein response are energetically challenging
under nutrient stress conditions. However, the regulatory mechanisms that control the …
under nutrient stress conditions. However, the regulatory mechanisms that control the …