User profiles for Jose Antonio Enriquez

José Antonio Enríquez

Centro Nacional de Investigaciones Cardiovasculares (CNIC)
Verified email at cnic.es
Cited by 20991

Supercomplex assembly determines electron flux in the mitochondrial electron transport chain

…, P Fernández-Silva, E Fernández-Vizarra, JA Enríquez - Science, 2013 - science.org
The textbook description of mitochondrial respiratory complexes (RCs) views them as free-moving
entities linked by the mobile carriers coenzyme Q (CoQ) and cytochrome c (cyt c). This …

[PDF][PDF] NDUFA4 is a subunit of complex IV of the mammalian electron transport chain

…, R Szklarczyk, E Calvo, MO Landázuri, JA Enríquez - Cell metabolism, 2012 - cell.com
The oxidative phosphorylation system is one of the best-characterized metabolic pathways.
In mammals, the protein components and X-ray structures are defined for all complexes …

Oxidative phosphorylation selectively orchestrates tissue macrophage homeostasis

…, A Curtabbi, C Barbas, NS Chandel, JA Enríquez… - Immunity, 2023 - cell.com
In vitro studies have associated oxidative phosphorylation (OXPHOS) with anti-inflammatory
macrophages, whereas pro-inflammatory macrophages rely on glycolysis. However, the …

[PDF][PDF] Respiratory active mitochondrial supercomplexes

…, ML Peleato, A Pérez-Martos, JA Enriquez - Molecular cell, 2008 - cell.com
The structural organization of the mitochondrial respiratory complexes as four big independently
moving entities connected by the mobile carriers CoQ and cytochrome c has been …

[PDF][PDF] Induction of the mitochondrial NDUFA4L2 protein by HIF-1α decreases oxygen consumption by inhibiting Complex I activity

…, E Perales-Clemente, A Martínez-Ruiz, JA Enríquez… - Cell metabolism, 2011 - cell.com
The fine regulation of mitochondrial function has proved to be an essential metabolic adaptation
to fluctuations in oxygen availability. During hypoxia, cells activate an anaerobic switch …

Multifaceted mitochondria: moving mitochondrial science beyond function and dysfunction

AS Monzel, JA Enríquez, M Picard - Nature metabolism, 2023 - nature.com
Mitochondria have cell-type specific phenotypes, perform dozens of interconnected
functions and undergo dynamic and often reversible physiological recalibrations. Given their …

MtDNA mutation in MERRF syndrome causes defective aminoacylation of tRNALys and premature translation termination

JA Enriquez, A Chomyn, G Attardi - Nature genetics, 1995 - nature.com
We have investigated the pathogenetic mechanism of the mitochondrial tRNA Lys gene
mutation (position 8344) associated with MERRF encephalomyopathy in several mitochondrial …

[PDF][PDF] Mutations of SURF-1 in Leigh disease associated with cytochrome c oxidase deficiency

…, M Rocchi, MP Bayona-Bafaluy, JA Enriquez… - The American Journal of …, 1998 - cell.com
Leigh disease associated with cytochrome c oxidase deficiency (LD [COX−] ) is one of the
most common disorders of the mitochondrial respiratory chain, in infancy and childhood. No …

Supramolecular organization of respiratory complexes

JA Enríquez - Annual Review of Physiology, 2016 - annualreviews.org
Since the discovery of the existence of superassemblies between mitochondrial respiratory
complexes, such superassemblies have been the object of a passionate debate. It is …

[PDF][PDF] ER and nutrient stress promote assembly of respiratory chain supercomplexes through the PERK-eIF2α axis

…, M Jedrychowski, SP Gygi, JA Enriquez… - Molecular cell, 2019 - cell.com
Endoplasmic reticulum (ER) stress and unfolded protein response are energetically challenging
under nutrient stress conditions. However, the regulatory mechanisms that control the …