Alzheimer’s disease is a pervasive neurodegenerative disorder, the molecular complexity of
which remains poorly understood. Here, we analysed 80,660 single-nucleus transcriptomes …

Tobacco and alcohol use are leading causes of mortality that influence risk for many complex
diseases and disorders 1 . They are heritable 2 , 3 and etiologically related 4 , 5 behaviors …

In Alzheimer’s disease, amyloid deposits along the brain vasculature lead to a condition known
as cerebral amyloid angiopathy (CAA), which impairs blood–brain barrier (BBB) function …

Genome-wide association studies (GWAS) have identified genetic variants associated with
age-related macular degeneration (AMD), one of the leading causes of blindness in the …

The epigenome and three-dimensional (3D) genomic architecture are emerging as key
factors in the dynamic regulation of different transcriptional programs required for neuronal …

APOE4 is the strongest genetic risk factor for Alzheimer’s disease 1 , 2 – 3 . However, the
effects of APOE4 on the human brain are not fully understood, limiting opportunities to develop …

The mechanisms by which mutant huntingtin (mHTT) leads to neuronal cell death in Huntington's
disease (HD) are not fully understood. To gain new molecular insights, we used single …

BACE-1 is required for generating β-amyloid (Aβ) peptides in Alzheimer’s disease (AD). Here,
we report that microglial BACE-1 regulates the transition of homeostatic to stage 1 disease…

The increasing availability of single-cell data revolutionizes the understanding of biological
mechanisms at cellular resolution. For differential expression analysis in multi-subject single-…

Recent increases in human longevity have been accompanied by a rise in the incidence of
dementia, highlighting the need to preserve cognitive function in an aging population. A …